Effect of Cyclophosphamide on miRNA-15a expression in EBV infected transformed B cell

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SOTOODEH JAHROMI ABDOLREZA; KARGAR MOHAMMAD; Moradzadeh Maliheh; KAFILZADEH FARSHID; JAMALIDOUST MARZIEH

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Journal: Pars Journal of Medical Sciences Year:2021 | Volume:19 | Issue:1 Page(s): 1-9

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Title

Effect of Cyclophosphamide on miRNA-15a expression in EBV infected transformed B cell

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Keywords

Cyclophosphamide

Micro-RNA

B Cell

Epstein Barr Virus

Abstract

Introduction: Despite advances in diagnosis and therapy of cancer, it is still the main cause of death worldwide. Cyclophosphamide is one of the major drugs for lymphoma treatment. However, the anti-lymphoma effects of Cyclophosphamide on Micro-RNA expression are still unclear, especially in B Cell lymphomas. The aim of the present study was to evaluate the effect of Cyclophosphamide on miRNA15a genes expression in Epstein‐ Barr‐ Virus (EBV)-infected transformed B Cell. Material and Methods: In this study, the effects of Cyclophosphamide on CO 88BV59-1 LCL – an EBV infected transformed B Cell was evaluated. The cells were treated with Cyclophosphamide (0. 05-50 µ M), for 3 days. The cell viability and cytotoxicity were evaluated using MTT, and flow cytometry techniques, respectively. Also, miRNA-15a genes expression were determined by real-time PCR. Results: Cyclophosphamide significantly inhibited proliferation and induced cell death in the cell-line in a dose and time-dependent manner (P<0. 05). There were no significant changes in the expression of miRNA15a3p and miRNA-15a5p in treated cells compared to untreated cells (P>0. 05). Conclusions: The results showed that cytotoxic effects of Cyclophosphamide on CO 88BV59-1 LCL is not related to miRNA-15a3p and miRNA-15a5p expressions.

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APA: Copy

SOTOODEH JAHROMI, ABDOLREZA, KARGAR, MOHAMMAD, Moradzadeh, Maliheh, KAFILZADEH, FARSHID, & JAMALIDOUST, MARZIEH. (2021). Effect of Cyclophosphamide on miRNA-15a expression in EBV infected transformed B cell. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 19(1 ), 1-9. SID. https://sid.ir/paper/956196/en

Vancouver: Copy

SOTOODEH JAHROMI ABDOLREZA, KARGAR MOHAMMAD, Moradzadeh Maliheh, KAFILZADEH FARSHID, JAMALIDOUST MARZIEH. Effect of Cyclophosphamide on miRNA-15a expression in EBV infected transformed B cell. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2021;19(1 ):1-9. Available from: https://sid.ir/paper/956196/en

IEEE: Copy

ABDOLREZA SOTOODEH JAHROMI, MOHAMMAD KARGAR, Maliheh Moradzadeh, FARSHID KAFILZADEH, and MARZIEH JAMALIDOUST, “Effect of Cyclophosphamide on miRNA-15a expression in EBV infected transformed B cell,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 19, no. 1 , pp. 1–9, 2021, [Online]. Available: https://sid.ir/paper/956196/en

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