The effect of osteocalcin on testis morphometry in azoospermic Syrian male NMRI

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Yaghobinejad Mahsa; Solhjoo Somayeh; Toolee Heidar; Bashghareh Alieh; Nohesara Aliasghar; RASTEGAR TAYEBEH

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Journal: JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:7 | Issue:1 (22) Page(s): 98-111

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Title

The effect of osteocalcin on testis morphometry in azoospermic Syrian male NMRI

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Keywords

osteocalcin

testis morphometery

azoospermy

busulfan

Abstract

Introduction The aim of this study was to evaluat the protective effect of osteocalcin on testis tissue in adult azoospemic mice. Method and materials 25 Adult male mice were divided into five groups: the control group received normal saline for two months, PBS-DMSO group(received DMSO and after 5weeks they received PBS for 30 days), and busulfan group received a single dose of 40mg/kg busulfan intra-peritoneally, and busulfan-PBS group received 40mg/kg busulfan and after 5 weeks PBS daily for a month, and the busulfanosteocalcin group received 3ng/g/d osteocalcin, daily for one month, 5 weeks after a single dose of busulfan. Finally, after removal of the testis, tissues were fixed in bouin solution and stained by H&E. the sections were evaluated, and morphometric tests were done. Results No significant reduction was found in body weights of the groups, however left testis weight in osteocalcin group showed significant raise in comparison with azoospermic group (P˂ 0. 05). More ever, significant increase in seminiferous tubule diameter was observed in the osteocalcin group in comparison with (P˂ 0. 05). Testicular epithelium height was significantly increased in the osteocalcin group in comparison with azoospermic group (P˂ 0. 05). There weren’ t any significant changes in sertoli, leidyg, myoid counting among all the groups. The total number of spermatocyte, round spermatid, elongated spermatid and spermatogonia cells showed significant increase in osteocalcin group in comparison with busulfan and busulfan-PBS groups (P˂ 0. 05). Conclusion osteocalcin can improve the cytotoxic effect of busulfan on spermatogenic. cells, also can improve spermatogenesis.

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APA: Copy

Yaghobinejad, Mahsa, Solhjoo, Somayeh, Toolee, Heidar, Bashghareh, Alieh, Nohesara, Aliasghar, & RASTEGAR, TAYEBEH. (2019). The effect of osteocalcin on testis morphometry in azoospermic Syrian male NMRI. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, 7(1 (22) ), 98-111. SID. https://sid.ir/paper/956197/en

Vancouver: Copy

Yaghobinejad Mahsa, Solhjoo Somayeh, Toolee Heidar, Bashghareh Alieh, Nohesara Aliasghar, RASTEGAR TAYEBEH. The effect of osteocalcin on testis morphometry in azoospermic Syrian male NMRI. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;7(1 (22) ):98-111. Available from: https://sid.ir/paper/956197/en

IEEE: Copy

Mahsa Yaghobinejad, Somayeh Solhjoo, Heidar Toolee, Alieh Bashghareh, Aliasghar Nohesara, and TAYEBEH RASTEGAR, “The effect of osteocalcin on testis morphometry in azoospermic Syrian male NMRI,” JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 1 (22) , pp. 98–111, 2019, [Online]. Available: https://sid.ir/paper/956197/en

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