HISTOLOGIC EFFECTS OF AMYGDALIN ON THE MOUSE LIVER

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RAJAEI F.; MASHAYEKHI F.; MOHAMMADIAN A.

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Title

HISTOLOGIC EFFECTS OF AMYGDALIN ON THE MOUSE LIVER

Author(s)

RAJAEI F. | MASHAYEKHI F. | MOHAMMADIAN A. | Issue Writer Certificate

Keywords

AMYGDALINQ2

HISTOLOGYQ2

MOUSEQ2

LIVERQ2

Abstract

Background and Aim: There are many controversial reports about the toxic effects of AMYGDALIN as an anticancer drug. The aim of the present study was to investigate the histological effects of AMYGDALIN on the MOUSE LIVER.Materials and Methods: Thirty two adult male mice were selected and divided into 4 equal groups control, 10 mg/kg A mygdalin group, 25 mg/kg A mygdalin group, and 50 mg/kg AMYGDALIN group; all AMYGDALIN groups injected intraperitoneally. The experimental groups were injected with the specified doses of A mygdalin for 30 days, while the control ones were injected with normal saline. Three days after the last injection, all animals were anaesthetized and their LIVERs weighed. Then, microscopic slides from their LIVERs were prepared. Their Kupffer, necrotic, and multinucleated hepatic cells were counted. The collected data was analyzed statistically using Kruskal- Wallis test and SPSS software (version 16).Results: There was no significant changes in the number of necrotic cells and mean weight of the LIVER in the study groups while the number of kupffer cells in A mygdalin 25 and 50 mg/kg groups significantly increased compared to A mygdalin 10 and the control (P=0.001).Moreover, mean number of multinucleated cells in A mygdalin 50 showed a statistically significant difference compared to the control (P=0.04).Conclusion: The present study showed that AMYGDALIN injection can dose-dependently cause an increase in the number of kupffer and multinucleated hepatic cells in the MOUSE.

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APA: Copy

RAJAEI, F., MASHAYEKHI, F., & MOHAMMADIAN, A.. (2012). HISTOLOGIC EFFECTS OF AMYGDALIN ON THE MOUSE LIVER. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 18(4 (49)), 242-249. SID. https://sid.ir/paper/95658/en

Vancouver: Copy

RAJAEI F., MASHAYEKHI F., MOHAMMADIAN A.. HISTOLOGIC EFFECTS OF AMYGDALIN ON THE MOUSE LIVER. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;18(4 (49)):242-249. Available from: https://sid.ir/paper/95658/en

IEEE: Copy

F. RAJAEI, F. MASHAYEKHI, and A. MOHAMMADIAN, “HISTOLOGIC EFFECTS OF AMYGDALIN ON THE MOUSE LIVER,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 4 (49), pp. 242–249, 2012, [Online]. Available: https://sid.ir/paper/95658/en

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