The effect of Troxerutin combined with high intensity interval training on heart injury and expression of antioxidant genes in doxorubicin-induced cardiac toxicity in male rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Taghavi Holagh Aboalghasem; Abed Natanzi Hossein; BADALZADEH REZA; GHAZALIAN FARSHAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2021 | Volume:29 | Issue:153 Page(s): 78-89

Download Full-Text

Persian Verion

View:

246

Download:

Cites:

Information Journal Paper

Title

The effect of Troxerutin combined with high intensity interval training on heart injury and expression of antioxidant genes in doxorubicin-induced cardiac toxicity in male rats

Author(s)

Taghavi Holagh Aboalghasem | Abed Natanzi Hossein | BADALZADEH REZA | GHAZALIAN FARSHAD | Issue Writer Certificate

Keywords

Doxorubicin

High-intensity interval training

Troxerutin

Cardiac Toxicity

Antioxidant genes

Abstract

Background and Objective: Cancers represent an important cause of morbidity and mortality, cause more than 12% of deaths in the world. Doxorubicin (DOX) is an effective drug in the treatment of various cancers whose usage has been limited due to Cardiac Toxicity. Troxerutin (TRX) is derived from rutin flavonoids and has multiplex pharmacological properties. The present study aimed to investigate the combined effect of Troxerutin and High-intensity interval training (HIIT) on DOX-induced Cardiac Toxicity and the expression of Antioxidant genes in rat hearts. Materials and Methods: Male Wistar rats were randomly divided into five groups (n = 10): 1) Control, 2) DOX, 3) HIIT + DOX, 4) TRX + DOX, and 5) HIIT + TRX + DOX. After the last session of HIIT, the trained and time-matched control rats were injected with DOX (20 mg/kg, ip). The Creatine kinase (CKMB) and Lactatedehydrogenase (LDH) changes were measured by spectrophotometry and ELISA. Expression of Antioxidant genes was measured by Real-Time PCR. Results: DOX injection increased serum CKMB and LDH in rats in comparison to the control group (P<0. 05) and (P <0. 01), respectively. HIIT exercise and Troxerutin, alone or in combination, reduced the serum CKMB and LDH levels (P<0. 05) and their combined effect was greater than those of individual treatments (P<0. 01). DOX injection decreased the expression of Nrf2 and Foxo1 Antioxidant genes as compared with a control group (P <0. 01). HIIT exercise and Troxerutin consumption alone increased the expression of the Foxo1 gene as compared with the DOX group (P <0. 05) and their combined effect was greater than either alone (P <0. 01). HIIT exercise and troxergotTroxerutin consumption alone increased the expression of the Nrf2 gene insignificantly, but their combined effect was significantly increased (P <0. 01). Conclusion: The combined effect of HIIT exercise and Troxerutin is a promising strategy to prevent DOX-induced Cardiac Toxicity and increase the expression of Antioxidant genes in rat hearts.

Cites

No record.

References

No record.

Cite

APA: Copy

Taghavi Holagh, Aboalghasem, Abed Natanzi, Hossein, BADALZADEH, REZA, & GHAZALIAN, FARSHAD. (2021). The effect of Troxerutin combined with high intensity interval training on heart injury and expression of antioxidant genes in doxorubicin-induced cardiac toxicity in male rats. DANESHVAR MEDICINE, 29(153 ), 78-89. SID. https://sid.ir/paper/958706/en

Vancouver: Copy

Taghavi Holagh Aboalghasem, Abed Natanzi Hossein, BADALZADEH REZA, GHAZALIAN FARSHAD. The effect of Troxerutin combined with high intensity interval training on heart injury and expression of antioxidant genes in doxorubicin-induced cardiac toxicity in male rats. DANESHVAR MEDICINE[Internet]. 2021;29(153 ):78-89. Available from: https://sid.ir/paper/958706/en

IEEE: Copy

Aboalghasem Taghavi Holagh, Hossein Abed Natanzi, REZA BADALZADEH, and FARSHAD GHAZALIAN, “The effect of Troxerutin combined with high intensity interval training on heart injury and expression of antioxidant genes in doxorubicin-induced cardiac toxicity in male rats,” DANESHVAR MEDICINE, vol. 29, no. 153 , pp. 78–89, 2021, [Online]. Available: https://sid.ir/paper/958706/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops