The Anxiolytic Effect of Alpha-Linoleic Acid in Alzheimer's Disease Model Rats is Mediated by Enhanced Brain-Derived Neurotrophic Factor Expression

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Tofighi Nahaleh; Asle Rousta Masoumeh; RAHNEMA MEHDI; Amini Rahim

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Journal: KNOWLEDGE AND HEALTH Year:2021 | Volume:16 | Issue:3 Page(s): 9-14

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Title

The Anxiolytic Effect of Alpha-Linoleic Acid in Alzheimer's Disease Model Rats is Mediated by Enhanced Brain-Derived Neurotrophic Factor Expression

Author(s)

Tofighi Nahaleh | Asle Rousta Masoumeh | RAHNEMA MEHDI | Amini Rahim | Issue Writer Certificate

Keywords

Alpha-linoleic acid

Anxiety

Brain-derived neurotropic factor

Amyloid beta peptide

Abstract

Introduction: The deposition of Amyloid beta peptide (Aβ ) in the brain is one of the hallmarks of Alzheimer's disease. In addition to inducing oxidative stress and inflammation, beta-amyloid reduces the expression of Brain-derived neurotropic factor (BDNF) and causes behavioral disorders such as Anxiety even before memory impairment. Alpha-linoleic acid is an omega-3 unsaturated fatty acid that has antioxidant, anti-inflammatory, and neuroprotective effects. This study aimed to investigate the effect of Alpha-linoleic acid on Anxiety induced by Aβ 1-42 and examined the possible role of BDNF in this effect. Methods: Male Wistar rats were divided into four groups included control, Alpha-linoleic acid, Aβ , and Aβ-Alpha-linoleic acid. After intra-hippocampal injection of Aβ 1-42, the animals received Alpha-linoleic acid subcutaneously at a dose of 150 µ g/kg. At the end of the course, the anxious behavior of the animals was assessed using an elevated plus-plus maze test and BDNF mRNA expression in the hippocampus was measured by real-time PCR. The significant level was set at 0. 05. Results: In the elevated plus-maze test, Alpha-linoleic acid significantly increased the percentage of open arm entry and the percentage of time spent in open arm in rats receiving Aβ 1-42 (P<0. 001). Alpha-linoleic acid also increased BDNF mRNA expression in the hippocampus of these animals (P<0. 05). Conclusion: Based on the results of the study, Alpha-linoleic acid has an anxiolytic effect in Alzheimer's disease model rats, and this effect is largely exerted by an increase in BDNF. Alpha-linoleic acid may be effective in reducing neurodegeneration.

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APA: Copy

Tofighi, Nahaleh, Asle Rousta, Masoumeh, RAHNEMA, MEHDI, & Amini, Rahim. (2021). The Anxiolytic Effect of Alpha-Linoleic Acid in Alzheimer's Disease Model Rats is Mediated by Enhanced Brain-Derived Neurotrophic Factor Expression. KNOWLEDGE AND HEALTH, 16(3 ), 9-14. SID. https://sid.ir/paper/960087/en

Vancouver: Copy

Tofighi Nahaleh, Asle Rousta Masoumeh, RAHNEMA MEHDI, Amini Rahim. The Anxiolytic Effect of Alpha-Linoleic Acid in Alzheimer's Disease Model Rats is Mediated by Enhanced Brain-Derived Neurotrophic Factor Expression. KNOWLEDGE AND HEALTH[Internet]. 2021;16(3 ):9-14. Available from: https://sid.ir/paper/960087/en

IEEE: Copy

Nahaleh Tofighi, Masoumeh Asle Rousta, MEHDI RAHNEMA, and Rahim Amini, “The Anxiolytic Effect of Alpha-Linoleic Acid in Alzheimer's Disease Model Rats is Mediated by Enhanced Brain-Derived Neurotrophic Factor Expression,” KNOWLEDGE AND HEALTH, vol. 16, no. 3 , pp. 9–14, 2021, [Online]. Available: https://sid.ir/paper/960087/en

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