Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a Mouse Model of Allergic Asthma: An experimental study

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Mazloomi Ebrahim; Rezapour Firouzi Soheila; KHERADMAND FATEMEH; DELIREZH NOWRUZ; SHAHABI SHAHRAM; ILKHANIZADEH BEHROOZ

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Journal: Studies in Medical Sciences Year:2019 | Volume:30 | Issue:5 Page(s): 355-363

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Title

Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a Mouse Model of Allergic Asthma: An experimental study

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Keywords

Allergy

Nicotine

mTORC2

STAT3

Abstract

Background & Aims: Allergic diseases have increased in the last decade worldwide and researchers have been trying to introduce new strategies and drugs to treat these types of diseases. Nicotine shows anti-inflammatory properties and the studies have revealed that it can reduce the inflammation and the allergic responses. The mammalian target of rapamycin (mTOR) is a multifunctional protein kinase that forms two complexes in the signaling pathway. It has been shown that mTOR Complex 2 (mTORC2) tends to promote the immune response toward Th2. Also, the studies have indicated that the signal transducer and activator of transcription 3 (STAT3) is an essential transcription factor in anti-inflammatory responses and Nicotine exert its anti-inflammatory effects using the STAT3 signaling pathway Materials & Methods: In this experimental Study, we investigated the effects of Nicotine on the expression RICTOR-mTORC2 and STAT3 genes in a mouse model of allergic asthma. The mice were sensitized using ovalbumin and alum and 2 weeks later treated tree times with Nicotine in the concentration of 10 mg/kg every other day. The mice were challenged with ovalbumin aerosols on days 35, 38 and 41 and sacrificed the next day Results: Our results showed that Nicotine treatment resulted in down-regulation of RICTOR-mTORC2 expression. Also, the results indicated that Nicotine could up-regulate the expression of STAT3 Conclusion: Such data proposed that Nicotine administration may decrease allergic responses and the inflammation in the airways of the allergic mice by down-regulating the expression of RICTOR-mTORC2 and up-regulating the expression of STAT3 genes.

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APA: Copy

Mazloomi, Ebrahim, Rezapour Firouzi, Soheila, KHERADMAND, FATEMEH, DELIREZH, NOWRUZ, SHAHABI, SHAHRAM, & ILKHANIZADEH, BEHROOZ. (2019). Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a Mouse Model of Allergic Asthma: An experimental study. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 30(5 ), 355-363. SID. https://sid.ir/paper/960291/en

Vancouver: Copy

Mazloomi Ebrahim, Rezapour Firouzi Soheila, KHERADMAND FATEMEH, DELIREZH NOWRUZ, SHAHABI SHAHRAM, ILKHANIZADEH BEHROOZ. Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a Mouse Model of Allergic Asthma: An experimental study. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2019;30(5 ):355-363. Available from: https://sid.ir/paper/960291/en

IEEE: Copy

Ebrahim Mazloomi, Soheila Rezapour Firouzi, FATEMEH KHERADMAND, NOWRUZ DELIREZH, SHAHRAM SHAHABI, and BEHROOZ ILKHANIZADEH, “Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a Mouse Model of Allergic Asthma: An experimental study,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 30, no. 5 , pp. 355–363, 2019, [Online]. Available: https://sid.ir/paper/960291/en

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