The effect of aerobic training and resveratrol on some regulatory and executive factors of cardiomyocytes apoptosis in STZ-diabetic male rats

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MEHRI ALI; Hosseinpour Delaware Sedigheh; Azizi Masoume; Azarbaijani Mohammad Ali; Farzangi Parvin

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2020 | Volume:30 | Issue:1 Page(s): 59-66

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Title

The effect of aerobic training and resveratrol on some regulatory and executive factors of cardiomyocytes apoptosis in STZ-diabetic male rats

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Keywords

Diabetes mellitus

Resveratrol

Aerobic exercise

BAX

Bcl-2

Caspase3

Abstract

Background: The present study was conducted to investigate the effect of aerobic training with Resveratrol supplementation on regulatory and executive factors of cardiomyocytes apoptosis in streptozocin diabetic male rats. Materials and methods: In an experimental study, 50 male rats were randomly divided into 5 groups of 10 healthy controls, diabetics, Resveratrol supplements, aerobic training and complementary Resveratrol + aerobic training. Diabetes was induced by single injection of streptozotocin (50 ml/kg). Training was done 5 days per week for 8 weeks. They did exercise on the treadmill at 15m/min, 5 min and gradient of 15%. At the end of the course, all animals were completely and similarly treated and 48 hours after the last training session, anesthetized and sacrificed. After cardiac out and homogenization, the concentration of BAX, Bcl-2 and Caspase3 was measured individually. Results: After induction of diabetes, the concentration of BAX and Caspase-3 significantly increased compared with healthy controls, while Bcl-2 concentration decreased significantly. However, only exercise interaction and Resveratrol had significant effect on BAX concentration and had no significant effect on Caspase-3 levels. Each exercise and Resveratrol separately increased Bcl-2 concentration, but their interactive effect was not significant. Conclusion: Aerobic exercise and Resveratrol have a beneficial effect on cardiac apoptosis in inducing diabetes, but their interaction is not significant in the process of cardiac apoptosis. Of course, Aerobic exercise and Resveratrol could be used as complementary therapies for myocardial protection against invasive apoptosis induced by diabetes.

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APA: Copy

MEHRI, ALI, Hosseinpour Delaware, Sedigheh, Azizi, Masoume, Azarbaijani, Mohammad Ali, & Farzangi, Parvin. (2020). The effect of aerobic training and resveratrol on some regulatory and executive factors of cardiomyocytes apoptosis in STZ-diabetic male rats. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 30(1 ), 59-66. SID. https://sid.ir/paper/961510/en

Vancouver: Copy

MEHRI ALI, Hosseinpour Delaware Sedigheh, Azizi Masoume, Azarbaijani Mohammad Ali, Farzangi Parvin. The effect of aerobic training and resveratrol on some regulatory and executive factors of cardiomyocytes apoptosis in STZ-diabetic male rats. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2020;30(1 ):59-66. Available from: https://sid.ir/paper/961510/en

IEEE: Copy

ALI MEHRI, Sedigheh Hosseinpour Delaware, Masoume Azizi, Mohammad Ali Azarbaijani, and Parvin Farzangi, “The effect of aerobic training and resveratrol on some regulatory and executive factors of cardiomyocytes apoptosis in STZ-diabetic male rats,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 30, no. 1 , pp. 59–66, 2020, [Online]. Available: https://sid.ir/paper/961510/en

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