EVALUATION OF ANTIOXIDANT AND ANTIFUNGAL PROPERTIES OF NEW DERIVATIVES OF PERAZOLO [3, 4-D] PYRIMIDINE

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Moghaddam manesh Mohammadreza; Hosseinzadegan Sara; Beyzaei Hamid

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Journal: Studies in Medical Sciences Year:2019 | Volume:30 | Issue:3 Page(s): 163-173

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Title

EVALUATION OF ANTIOXIDANT AND ANTIFUNGAL PROPERTIES OF NEW DERIVATIVES OF PERAZOLO [3, 4-D] PYRIMIDINE

Author(s)

Moghaddam manesh Mohammadreza | Hosseinzadegan Sara | Beyzaei Hamid | Issue Writer Certificate

Keywords

Antioxidant activity

antifungal activity

new heterocyclic compounds

perazolo[3

4d]pyrimidine

Abstract

Background & Aims: Heterocyclic compounds are found be abundant in nature, these compounds have many biological properties, and many drugs also contain heterocyclic rings. In this study, antioxidant and anti-fungal properties of the seven pyrazolo[3, 4-d]pyrimidine compounds has been studied that synthesized in Iran and their good antibacterial properties have been reported Materials & Methods: Antioxidant properties were evaluated using the DPPH (2, 2-diphenyl-1picrylhydrazyl) method. Antifungal property was evaluated using CLSI (Clinical & Laboratory Standards Institut) standard based on inhibition zone diameter, minimum inhibitory concentration and minimum fungicidal concentration and compared with anti-fungal drugs including Ketoconazole, Nystatin and Tolnaftate. Results: Concentrations of 25, 50, 75 and 100 μ g/mL of the derivatives were prepared in methanol, after performing an antioxidant test with DPPH, the percentage of inhibition was reported, in addition, the IC50 was calculated for each compound, and finally the test for ascorbic acid was done and the results were compared. In the study of antifungal activity, after the preparation of specific concentrations of derivatives, the results of inhibition zone diameter, minimum inhibitory concentration and minimum fungicidal concentration were reported and the tests were performed for Ketoconazole, Nystatin and Tolnaftate drugs and finally the results of the derivatives with the drugs were compared. Conclusion: In this study, new synthetic compounds of pyrazolo[3, 4-d]pyrimidine showed Antioxidant activity. In addition, these compounds have strong antifungal properties, and even some derivatives have better results and effective than anti-fungal commercial drugs.

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APA: Copy

Moghaddam manesh, Mohammadreza, Hosseinzadegan, Sara, & Beyzaei, Hamid. (2019). EVALUATION OF ANTIOXIDANT AND ANTIFUNGAL PROPERTIES OF NEW DERIVATIVES OF PERAZOLO [3, 4-D] PYRIMIDINE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 30(3 ), 163-173. SID. https://sid.ir/paper/962206/en

Vancouver: Copy

Moghaddam manesh Mohammadreza, Hosseinzadegan Sara, Beyzaei Hamid. EVALUATION OF ANTIOXIDANT AND ANTIFUNGAL PROPERTIES OF NEW DERIVATIVES OF PERAZOLO [3, 4-D] PYRIMIDINE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2019;30(3 ):163-173. Available from: https://sid.ir/paper/962206/en

IEEE: Copy

Mohammadreza Moghaddam manesh, Sara Hosseinzadegan, and Hamid Beyzaei, “EVALUATION OF ANTIOXIDANT AND ANTIFUNGAL PROPERTIES OF NEW DERIVATIVES OF PERAZOLO [3, 4-D] PYRIMIDINE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 30, no. 3 , pp. 163–173, 2019, [Online]. Available: https://sid.ir/paper/962206/en

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