EVALUATION OF HEPATOKINE AND LIVER ENZYMES CHANGES IN OBESE RATS WITH THE HIGH-FAT DIET TO DIFFERENT TRAINING MODALITIES: AN EXPERIMENTAL STUDY

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Ehsani Far Mahsa; Habibi Maleki Aref; TOFIGHI ASGHAR; KHADEM ANSARI MOHAMMAD HASAN; TOLOUEI AZAR JAVAD

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Journal: Studies in Medical Sciences Year:2019 | Volume:30 | Issue:6 Page(s): 487-501

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Title

EVALUATION OF HEPATOKINE AND LIVER ENZYMES CHANGES IN OBESE RATS WITH THE HIGH-FAT DIET TO DIFFERENT TRAINING MODALITIES: AN EXPERIMENTAL STUDY

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Keywords

Fetuin

FGF

high

intensity continues training

moderate

intensity continues training

high

intensity interval training

Abstract

Background & Aims: Exercise with modulation of hepatokine counteracts pathological abnormalities of the liver due to fat accumulation. Therefore, the purpose of this study was to investigate the effect of high-intensity continuous training (HICT), high-intensity interval training (HIIT), and moderateintensity continuous training (MICT) on Fetuin-A, FGF-21 and liver enzymes of the obese rats with high-fat diet. Materials & Methods: A total of 25 male Wistar rats were divided into 5 groups: 1) healthy control; 2) high-Fat Diet (HFD) control; 3) HICT; 4) HIIT and 5) MICT. Except for the healthy control group, all rats were subjected to the high-fat diet for 12 weeks and then the training rats were trained for 12 weeks, 5 sessions a week. Fetuin-A and FGF-21 values were measured by the ELISA method. Data were analyzed by dependent t-test and one-way ANOVA at a significance level of P≤ 0. 05. Results: The results of the ANOVA test showed that there is a significant difference between groups in Fetuin-A (P = 0. 001 and F=7. 670) and FGF-21 (P= 0. 010 and F=4. 394). It was also found that different training modalities had a different effect on hepatokine (MICT: a significant reduce in Fetuin-A and HICT: a significant increase in FGF-21) and had the same effect on ALT and AST. The HFD control significantly increased liver enzymes (P= 0. 001). However, all the exercise types significantly decreased these enzymes (for all groups, P= 0. 001). Conclusion: MICT exercises are more capable of controlling liver negative hepatokine such as FetuinA that prevent insulin resistance. However highintensity exercises such as HICT can increase the positive factors, such as FGF-21, that modifies the activity of the liver enzymes. As a result, it seems that obese subjects can use moderate to high-intensity exercises to prevent fatty liver.

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APA: Copy

Ehsani Far, Mahsa, Habibi Maleki, Aref, TOFIGHI, ASGHAR, KHADEM ANSARI, MOHAMMAD HASAN, & TOLOUEI AZAR, JAVAD. (2019). EVALUATION OF HEPATOKINE AND LIVER ENZYMES CHANGES IN OBESE RATS WITH THE HIGH-FAT DIET TO DIFFERENT TRAINING MODALITIES: AN EXPERIMENTAL STUDY. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 30(6 ), 487-501. SID. https://sid.ir/paper/962352/en

Vancouver: Copy

Ehsani Far Mahsa, Habibi Maleki Aref, TOFIGHI ASGHAR, KHADEM ANSARI MOHAMMAD HASAN, TOLOUEI AZAR JAVAD. EVALUATION OF HEPATOKINE AND LIVER ENZYMES CHANGES IN OBESE RATS WITH THE HIGH-FAT DIET TO DIFFERENT TRAINING MODALITIES: AN EXPERIMENTAL STUDY. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2019;30(6 ):487-501. Available from: https://sid.ir/paper/962352/en

IEEE: Copy

Mahsa Ehsani Far, Aref Habibi Maleki, ASGHAR TOFIGHI, MOHAMMAD HASAN KHADEM ANSARI, and JAVAD TOLOUEI AZAR, “EVALUATION OF HEPATOKINE AND LIVER ENZYMES CHANGES IN OBESE RATS WITH THE HIGH-FAT DIET TO DIFFERENT TRAINING MODALITIES: AN EXPERIMENTAL STUDY,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 30, no. 6 , pp. 487–501, 2019, [Online]. Available: https://sid.ir/paper/962352/en

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