Effects of alcoholic extract of Alhagi maurorum on the expression level of hepatic Caspase-3 gene in male Wistar rats following the induction of diabetes mellitus

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHRIVAR TAHMOORES; MOKHTARI MOKHTAR; Alipour Vally

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2021 | Volume:30 | Issue:4 Page(s): 408-417

Download Full-Text

Persian Verion

View:

190

Download:

Cites:

Information Journal Paper

Title

Effects of alcoholic extract of Alhagi maurorum on the expression level of hepatic Caspase-3 gene in male Wistar rats following the induction of diabetes mellitus

Author(s)

SHAHRIVAR TAHMOORES | MOKHTARI MOKHTAR | Alipour Vally | Issue Writer Certificate

Keywords

Alhagi maurorum

Streptozotocin

Caspase-3

βactine

Rat

Abstract

Background: Many diseases, including diabetes, are involve in the development of liver disorders through changes in the expression of genes such as Caspase-3. In the present study, the impact of alcoholic extract of Alhagi maurorum on the expression level of liver Caspase-3 gene was investigated in male Wistar Rats following the induction of diabetes mellitus by Streptozotocin. Materials and methods: In this experimental study, 42 male Wistar Rats were divided into 6 groups. The control group was left untreated, the diabetic control group received one dose of 70 mg/kg Streptozotocin, the experimental groups 1 and 2 received 250 and 500 mg/kg Alhagi maurorum alcoholic extract peritoneally respectively, and the experimental groups 3 and 4 first received Streptozotocin followed by 250 and 500 mg/kg extracts respectively. To investigate the expression level of the Caspase-3 gene, liver samples were obtained from all the groups, and were evaluated using real time PCR. Results: The expression of Caspase-3 gene, against β actine, increased significantly in experimental groups compared to the control group, while diabetic groups received extract showed reduced gene expression compared to the Streptozotocin group. Conclusion: It appears that Alhagi maurorum extract is effective in reducing hepatic gene expression of Caspase-3, which increases after using Streptozotocin. This effect is possibly due to the anti-oxidants contents, such as flavonoids and anthocyanins.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAHRIVAR, TAHMOORES, MOKHTARI, MOKHTAR, & Alipour, Vally. (2021). Effects of alcoholic extract of Alhagi maurorum on the expression level of hepatic Caspase-3 gene in male Wistar rats following the induction of diabetes mellitus. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 30(4 ), 408-417. SID. https://sid.ir/paper/962925/en

Vancouver: Copy

SHAHRIVAR TAHMOORES, MOKHTARI MOKHTAR, Alipour Vally. Effects of alcoholic extract of Alhagi maurorum on the expression level of hepatic Caspase-3 gene in male Wistar rats following the induction of diabetes mellitus. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2021;30(4 ):408-417. Available from: https://sid.ir/paper/962925/en

IEEE: Copy

TAHMOORES SHAHRIVAR, MOKHTAR MOKHTARI, and Vally Alipour, “Effects of alcoholic extract of Alhagi maurorum on the expression level of hepatic Caspase-3 gene in male Wistar rats following the induction of diabetes mellitus,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 30, no. 4 , pp. 408–417, 2021, [Online]. Available: https://sid.ir/paper/962925/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops