Survey on the interaction effect of low doses of ketamine on morphine-induced polycystic ovary syndrome in rat

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Bakhtyari Masoumeh; KARAMI MANIZHEH; JALALI NADOUSHAN MOHAMMADREZA; Babaei Sosahab Fatemeh

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2021 | Volume:29 | Issue:154 Page(s): 29-41

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Title

Survey on the interaction effect of low doses of ketamine on morphine-induced polycystic ovary syndrome in rat

Author(s)

Bakhtyari Masoumeh | KARAMI MANIZHEH | JALALI NADOUSHAN MOHAMMADREZA | Babaei Sosahab Fatemeh | Issue Writer Certificate

Keywords

Morphine

Ketamine

low dose

polycystic ovary syndrome

Rat

Abstract

Background and Objective: Morphine can induce PCOS (polycystic ovary syndrome) probably by changing glutamate level at the hypothalamic nuclei. This study used low doses of Ketamine to survey the interaction of Ketamine with Morphine-induced PCOS. Materials and Methods: 48 female Wistar Rats were selected as virgins in the weight range of 220-250 g, and categorized randomly into eight groups. The first group received Morphine (5 mg/kg) intraperitoneally. The second to fourth groups received Ketamine (1, 2, and 4 mg/kg). In groups 5 to 7, the Ketamine (1, 2, and 4 mg/kg) was pre-injected to Morphine (5 mg/kg) over a period of 20 min. Control group received only saline (1 ml/kg). After 48 h, the blood and serum specimens were provided to record hormone levels, and the animals’ ovaries and uteri were biometrically examined and stained by H & E. Statistical analysis was performed by analysis of variance (ANOVA) under α =0. 05. Results: The Morphine as well as single Ketamine induced the PCOS. However, taking Ketamine prior to Morphine caused a meaningful reduction in the number of cysts in the ovary. There was also a relative increase in uterine diameter in the group receiving Morphine, which was stopped due to Ketamine pre-treatment. These effects showed correlation with decreased levels of FSH, and change in estrogen, and prolactin amounts. Conclusion: The interference effect of Ketamine with Morphine is completely dependent on changes in gonadotropin level.

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APA: Copy

Bakhtyari, Masoumeh, KARAMI, MANIZHEH, JALALI NADOUSHAN, MOHAMMADREZA, & Babaei Sosahab, Fatemeh. (2021). Survey on the interaction effect of low doses of ketamine on morphine-induced polycystic ovary syndrome in rat. DANESHVAR MEDICINE, 29(154 ), 29-41. SID. https://sid.ir/paper/963155/en

Vancouver: Copy

Bakhtyari Masoumeh, KARAMI MANIZHEH, JALALI NADOUSHAN MOHAMMADREZA, Babaei Sosahab Fatemeh. Survey on the interaction effect of low doses of ketamine on morphine-induced polycystic ovary syndrome in rat. DANESHVAR MEDICINE[Internet]. 2021;29(154 ):29-41. Available from: https://sid.ir/paper/963155/en

IEEE: Copy

Masoumeh Bakhtyari, MANIZHEH KARAMI, MOHAMMADREZA JALALI NADOUSHAN, and Fatemeh Babaei Sosahab, “Survey on the interaction effect of low doses of ketamine on morphine-induced polycystic ovary syndrome in rat,” DANESHVAR MEDICINE, vol. 29, no. 154 , pp. 29–41, 2021, [Online]. Available: https://sid.ir/paper/963155/en

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