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Information Journal Paper

Title

The Effect of Intense Continuous and Interval Training on the Levels of Brain-Derived Neurotrophic Factor (BDNF) and Tumor Necrosis Factor Alpha (TNF-α ) in Hippocampus of Old Rats

Pages

  414-420

Abstract

 Background: The present study aimed to evaluate the effect of intense continuous and interval training on the levels of Brain-derived neurotrophic factor (BDNF) and Tumor Necrosis Factor Alpha (TNF-α ) in hippocampus of old Rats. Methods: 30 old male Wistar Rats (18 weeks old) were divided into 3 groups of interval training, continuous training, and control. Continuous training was performed for 8 weeks with 65% to 70% VO2max and interval training was performed 8 weeks with 5-8 repetitions of 2 minutes of working with 80%-100% VO2max and 2 minutes active rest with 50% of VO2max. Hippocampal samples were extracted 48 hours after the last training session to measure protein levels of BDNF and TNF-α . One-way ANOVA and Tukey post hoc tests were used for data analysis. Findings: Hippocampus BDNF levels in continuous (P = 0. 002) and interval training (P = 0. 003) groups were significantly higher than the control group. But no significant differences were found in BDNF levels between continuous and interval training groups (P = 0. 361). TNF-α levels in continuous and interval training groups were significantly higher than the control group (P = 0. 001 for both). But no significant differences were found in TNF-α levels between continuous and interval training groups (P = 0. 639). Conclusion: Intense continuous and interval training increase BDNF levels in the hippocampus of the elderly Rats through increasing TNF-α levels; thus, intense continuous and interval training can prevent aging of the nervous system by improving BDNF levels.

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    APA: Copy

    Moradi, Maysa, YAGHOUBI, ALI, & JALILVAND, MOHAMMADREZA. (2021). The Effect of Intense Continuous and Interval Training on the Levels of Brain-Derived Neurotrophic Factor (BDNF) and Tumor Necrosis Factor Alpha (TNF-α ) in Hippocampus of Old Rats. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 39(628 ), 414-420. SID. https://sid.ir/paper/963169/en

    Vancouver: Copy

    Moradi Maysa, YAGHOUBI ALI, JALILVAND MOHAMMADREZA. The Effect of Intense Continuous and Interval Training on the Levels of Brain-Derived Neurotrophic Factor (BDNF) and Tumor Necrosis Factor Alpha (TNF-α ) in Hippocampus of Old Rats. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2021;39(628 ):414-420. Available from: https://sid.ir/paper/963169/en

    IEEE: Copy

    Maysa Moradi, ALI YAGHOUBI, and MOHAMMADREZA JALILVAND, “The Effect of Intense Continuous and Interval Training on the Levels of Brain-Derived Neurotrophic Factor (BDNF) and Tumor Necrosis Factor Alpha (TNF-α ) in Hippocampus of Old Rats,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 39, no. 628 , pp. 414–420, 2021, [Online]. Available: https://sid.ir/paper/963169/en

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