Assessment of the Effects of Cyclooxygenase Inhibitors on the Immune Status Following Surgery in Adult Male Rats

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Abyari Mohammad; Alimohammadi Samad; Pooyanmehr Mehrdad; Ghashghaii Ali; MALEKI ALI

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2021 | Volume:15 | Issue:2 Page(s): 110-119

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Title

Assessment of the Effects of Cyclooxygenase Inhibitors on the Immune Status Following Surgery in Adult Male Rats

Author(s)

Keywords

Immune system

Cyclooxygenase inhibitors

Surgery

Rat

Abstract

Background and Objectives Surgery via different mechanisms causes immunosuppression in the postopeRative period. The aim of the present study was to investigate the effects of preopeRative administRation of Cyclooxygenase inhibitors on blood levels of Interleukin-2 (IL-2), Interferon-γ (IFN-γ ), Tumor Necrosis Factor-α (TNF-α ), white blood cells (WBCs) and lymphocytes. Methods Seventy-five male Wistar Rats were divided into five groups (n=15 for each group). Group 1 was gavaged with normal saline for 3 consecutive days without Surgery. Group 2 was gavaged with normal saline for 3 consecutive days. Groups 3 to 5 were gavaged with indomethacin (4 mg/kg) and celecoxib (7. 5 and 15 mg/kg), respectively, for 3 consecutive days. In Groups 2 to 5, one hour after drugs administRation on the third day, laparotomy was used as a Surgery pattern. Blood samples were collected 24 hours after Surgery and levels IL-2, IFN-γ , TNF-α , WBCs and lymphocytes were determined. Data were analyzed using one-way ANOVA test. Results Based on the results, a decrease in blood levels of IL-2, IFN-γ and lymphocytes along with an increase in TNF-α and WBCs were observed 24 hours after Surgery compared to control Rats (P<0. 05). Indomethacin (4 mg/kg) and celecoxib (15 mg/kg) improved the decreased level of IL-2 (P<0. 05). There was no significant difference in IFN-γ and lymphocytes between Surgery group and the groups treated with indomethacin or celecoxib (P>0. 05). Also, only celecoxib (15 mg/kg) could decrease the elevated levels TNF-α and WBCs (P<0. 05). Conclusion PeriopeRative use of Cyclooxygenase inhibitors can improve Immune system function

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APA: Copy

Abyari, Mohammad, Alimohammadi, Samad, Pooyanmehr, Mehrdad, Ghashghaii, Ali, & MALEKI, ALI. (2021). Assessment of the Effects of Cyclooxygenase Inhibitors on the Immune Status Following Surgery in Adult Male Rats. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 15(2 ), 110-119. SID. https://sid.ir/paper/963643/en

Vancouver: Copy

Abyari Mohammad, Alimohammadi Samad, Pooyanmehr Mehrdad, Ghashghaii Ali, MALEKI ALI. Assessment of the Effects of Cyclooxygenase Inhibitors on the Immune Status Following Surgery in Adult Male Rats. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2021;15(2 ):110-119. Available from: https://sid.ir/paper/963643/en

IEEE: Copy

Mohammad Abyari, Samad Alimohammadi, Mehrdad Pooyanmehr, Ali Ghashghaii, and ALI MALEKI, “Assessment of the Effects of Cyclooxygenase Inhibitors on the Immune Status Following Surgery in Adult Male Rats,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 15, no. 2 , pp. 110–119, 2021, [Online]. Available: https://sid.ir/paper/963643/en

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