Evaluation of Bone Marrow Absorbed Dose of 153 Sm-EDTMP and 223 Ra-Cl2 in Patients with Bone Metastasis Using Monte Carlo Simulation

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Dalvand Saman; Elmtalab Soheil; ZAMANI HAMED; Shahverdi Ebrahim; Malekzadeh Etesam

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2021 | Volume:39 | Issue:611 Page(s): 48-54

Download Full-Text

Persian Verion

View:

327

Download:

Cites:

Information Journal Paper

Title

Evaluation of Bone Marrow Absorbed Dose of 153 Sm-EDTMP and 223 Ra-Cl2 in Patients with Bone Metastasis Using Monte Carlo Simulation

Author(s)

Keywords

Palliative therapy

Monte Carlo methode

Radiopharmaceuticals

Radiation dosimetry

Abstract

Background: Targeted radiopharmaceutical therapy is one of the most common methods for relieving pain in patients with bone metastasis. In this type of treatment, the bone marrow absorbed dose, as a critical organ, needs to be considered as a limiting factor. Until now, beta-emitter Radiopharmaceuticals have been considered for this treatment modality, which one of the most commons is samarium-153-ethylene diamine tetramethylene phosphonate ( 153 Sm-EDTMP), but recently the radium-223-dichloride ( 223 Ra-Cl2) alpha emitter radiopharmaceutical has been approved by the US Food and Drug Administration (FDA). The aim of this study was to compare the bone marrow absorbed dose of 153 223 Sm-EDTMP and Ra-Cl2 Radiopharmaceuticals. Methods: In this study, a lumbar vertebral bone phantom was used for simulation. The Radiopharmaceuticals were distributed in the phantom, and the simulation was performed using the GATE Monte Carlo toolkit. After estimating the absorbed dose per decay in different parts of the phantom, the absorbed dose of Radiopharmaceuticals in the bone marrow of a patient with 70 kg weight, was calculated using the Medical Internal Radiation dosimetry (MIRD) method. 153 Findings: For Sm-EDTMP, the bone marrow absorbed dose was equal to 9. 60 Gy for the administered activity of 2590 MBq. For 223 Ra-Cl2, the bone marrow absorbed dose was calculated as 0. 83 Gy for administered activity of 3. 85 MBq. Conclusion: Due to the lower bone marrow absorbed dose by 223 Ra-Cl2 alpha emitter radiopharmaceutical, the use of this radiopharmaceutical as an alternative to 153 Sm-EDTMP beta emitter radiopharmaceutical is recommended for Palliative therapy of patients with bone metastasis.

Cites

No record.

References

No record.

Cite

APA: Copy

Dalvand, Saman, Elmtalab, Soheil, ZAMANI, HAMED, Shahverdi, Ebrahim, & Malekzadeh, Etesam. (2021). Evaluation of Bone Marrow Absorbed Dose of 153 Sm-EDTMP and 223 Ra-Cl2 in Patients with Bone Metastasis Using Monte Carlo Simulation. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 39(611 ), 48-54. SID. https://sid.ir/paper/963960/en

Vancouver: Copy

Dalvand Saman, Elmtalab Soheil, ZAMANI HAMED, Shahverdi Ebrahim, Malekzadeh Etesam. Evaluation of Bone Marrow Absorbed Dose of 153 Sm-EDTMP and 223 Ra-Cl2 in Patients with Bone Metastasis Using Monte Carlo Simulation. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2021;39(611 ):48-54. Available from: https://sid.ir/paper/963960/en

IEEE: Copy

Saman Dalvand, Soheil Elmtalab, HAMED ZAMANI, Ebrahim Shahverdi, and Etesam Malekzadeh, “Evaluation of Bone Marrow Absorbed Dose of 153 Sm-EDTMP and 223 Ra-Cl2 in Patients with Bone Metastasis Using Monte Carlo Simulation,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 39, no. 611 , pp. 48–54, 2021, [Online]. Available: https://sid.ir/paper/963960/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops