CD44 expression changes and increased apoptosis in MCF-7 cell line of breast cancer in simulated microgravity condition

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HAJEBRAHIMI ZAHRA; SALAVATIFAR MARYAM

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Journal Paper

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Journal: Pars Journal of Medical Sciences Year:2019 | Volume:17 | Issue:3 Page(s): 26-34

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Information Journal Paper

Title

CD44 expression changes and increased apoptosis in MCF-7 cell line of breast cancer in simulated microgravity condition

Author(s)

HAJEBRAHIMI ZAHRA | SALAVATIFAR MARYAM | Issue Writer Certificate

Keywords

Breast Cancer

Weightlessness

CD44

Apoptosis

Abstract

Introduction: CD44 molecule plays a role in cell adhesion and conduction of growth and cell signaling pathways and is involved in many types of cancers including Breast Cancer, which is highly expressed in invasive basal tumors. Simulated microgravity (Weightlessness) affects tumor cell proliferation and metastasis and has been introduced in recent years as a new method to study the growth and proliferation of cancer cells. Therefore, the aim of the present study was to investigate the gene expression of CD44 and the level of Apoptosis in MCF-7 Breast Cancer cell line under simulated microgravity condition. Materials and Methods: MCF-7 cell line was proliferated under normal gravity and microgravity (1 and 3 days) using clinostat apparatus. Gene expression and Apoptosis was measured using real-time PCR technique and Annexin V staining kit. Results: The results showed that microgravity reduce gene expression (50%) after 1 day and increased it four times after 3 days. Also, the level of Apoptosis was increased 40% after 1 day of microgravity. Conclusion: It seems that the response of cancer cells to microgravity can be time dependent and microgravity treatment for 1 day on MCF-7 cell line may have positive effects on reducing the phenotype of cancer in this cell line and can consider as a new way for cancer therapy.

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APA: Copy

HAJEBRAHIMI, ZAHRA, & SALAVATIFAR, MARYAM. (2019). CD44 expression changes and increased apoptosis in MCF-7 cell line of breast cancer in simulated microgravity condition. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 17(3 ), 26-34. SID. https://sid.ir/paper/964640/en

Vancouver: Copy

HAJEBRAHIMI ZAHRA, SALAVATIFAR MARYAM. CD44 expression changes and increased apoptosis in MCF-7 cell line of breast cancer in simulated microgravity condition. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2019;17(3 ):26-34. Available from: https://sid.ir/paper/964640/en

IEEE: Copy

ZAHRA HAJEBRAHIMI, and MARYAM SALAVATIFAR, “CD44 expression changes and increased apoptosis in MCF-7 cell line of breast cancer in simulated microgravity condition,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 17, no. 3 , pp. 26–34, 2019, [Online]. Available: https://sid.ir/paper/964640/en

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