THE STUDY OF LIPID PEROXIDATION LEVEL IN ERYTHROCYTES OF PATIENTS WITH IRON DEFICIENCY ANEMIA AND MAJOR -Β -THALASSEMIA AND PROTECTIVE ROLE OF VITAMIN E IN THIS PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHOFRANI S.; REZAZADEH M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Annals of Military and Health Sciences Research Year:2004 | Volume:1 | Issue:4 (Serial Number 4) Page(s): 231-236

Download Full-Text

Persian Verion

View:

944

Download:

Cites:

Information Journal Paper

Title

THE STUDY OF LIPID PEROXIDATION LEVEL IN ERYTHROCYTES OF PATIENTS WITH IRON DEFICIENCY ANEMIA AND MAJOR -Β -THALASSEMIA AND PROTECTIVE ROLE OF VITAMIN E IN THIS PATIENTS

Author(s)

GHOFRANI S. | REZAZADEH M. | Issue Writer Certificate

Keywords

LIPID PEROXIDATIONQ3

ERYTHROCYTESQ3

MAJOR Β-THALASEMIAQ3

IRON DEFICIENT ANEMIAQ4

Abstract

Background: LIPID PEROXIDATION (LP) is the major cause of damages to cell membrane that may lead to cell death. Reactive radicals generated in cell membrane can initiate oxidation of membrane polyunsaturated fatty acids (PUFA). Formation of hydroperoxides through free radical chain reaction causes modification of membrane molecules. ERYTHROCYTES derived from normal individuals and certain patients react differently to the damages caused by LP products. These differences could be attributed to the efficiency of the antioxidant activity in the cells. In this study the rate of LP formation and antioxidant system change Was compared in RBCs obtained from MAJOR Β-THALASEMIA, IRON DEFICIENT ANEMIA (IDA) and control group;(n=30in each group). Materials and Methods: LIPID PEROXIDATION was measured using thiobarbituric acid (TBA) reagent with spectorophotometric method. Results: Incubation of RBCs in presence of H2O2 shows that the concentration of malondialdehyde (MDA), the main LP product, is significantly higher in RBCs obtained from patients as compared to control group. Increased LP formation in major β -thalasemic and Iron deficient patients was 43% and 22% respectively. Conclusion: Correlation between LP formation and antioxidant activities was investigated in vitro, in presence and absence of various antioxidants such as; reduced glutathione, albumin and alpha-tocopherol. Both glutathione and catalase activities were lower in RBCs derived from patients as compared to their respective controls. According to the results vitamin E have a positive role in patients with MAJOR Β-THALASEMIA.

Cites

No record.

References

No record.

Cite

APA: Copy

GHOFRANI, S., & REZAZADEH, M.. (2004). THE STUDY OF LIPID PEROXIDATION LEVEL IN ERYTHROCYTES OF PATIENTS WITH IRON DEFICIENCY ANEMIA AND MAJOR -Β -THALASSEMIA AND PROTECTIVE ROLE OF VITAMIN E IN THIS PATIENTS. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 1(4 (Serial Number 4)), 231-236. SID. https://sid.ir/paper/96491/en

Vancouver: Copy

GHOFRANI S., REZAZADEH M.. THE STUDY OF LIPID PEROXIDATION LEVEL IN ERYTHROCYTES OF PATIENTS WITH IRON DEFICIENCY ANEMIA AND MAJOR -Β -THALASSEMIA AND PROTECTIVE ROLE OF VITAMIN E IN THIS PATIENTS. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2004;1(4 (Serial Number 4)):231-236. Available from: https://sid.ir/paper/96491/en

IEEE: Copy

S. GHOFRANI, and M. REZAZADEH, “THE STUDY OF LIPID PEROXIDATION LEVEL IN ERYTHROCYTES OF PATIENTS WITH IRON DEFICIENCY ANEMIA AND MAJOR -Β -THALASSEMIA AND PROTECTIVE ROLE OF VITAMIN E IN THIS PATIENTS,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 1, no. 4 (Serial Number 4), pp. 231–236, 2004, [Online]. Available: https://sid.ir/paper/96491/en

Related Journal Papers