EVALUATION OF TOXICITY CHEMICAL SUBSTANCES (EXTRACT OIHYNDROPYRIDINE DERIVATIVES, SAFF FLOWER AND PEGANUM HARMALA) BY SACCHAROMYCES CEREVISIAE

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DARABI N.; FALAHATI M.; MAHMOUDIAN M.

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Journal Paper

Paper Information

Journal: Annals of Military and Health Sciences Research Year:2007 | Volume:5 | Issue:1 (SERIAL NUMBER 17) Page(s): 1111-1114

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Title

EVALUATION OF TOXICITY CHEMICAL SUBSTANCES (EXTRACT OIHYNDROPYRIDINE DERIVATIVES, SAFF FLOWER AND PEGANUM HARMALA) BY SACCHAROMYCES CEREVISIAE

Author(s)

DARABI N. | FALAHATI M. | MAHMOUDIAN M. | Issue Writer Certificate

Keywords

DIHYDROPYRIDINE DERIVATIVESQ3

HARMALAQ3

LABORATORY ANIMALSQ2

PEGANUMQ3

SACCHAROMYCES CEREVISIAEQ3

SAFF FLOWERQ3

TOXICITYQ3

Abstract

Background: The TOXICITY of many chemical substances has been studied by many of living organisms used as biological indicators. Higher organisms (laboratory animals) are generally used but the response time may be lengthy. Never the less by exploiting uni cellular organisms, in particulary yeast, it is possible to reduce testing time considerably. In this study, the budding yeast, SACCHAROMYCES CEREVISIAE asimple non-pathogenic eukaryotic organisms, which is easy to cultivate, has been used as experimental model for assaying acute TOXICITY of chemical substances.Material & Methods: As a experimental study, The first step yeast cells were cultured in broth media and correlation cell of numbers and optical density was determined in 525 nm. Then, yeast cells were cultured in the presence of various concentration of chemical substances and cell density was measured. the proliferation rate determined from the logarithmic growth phase. A dose-response curve was obtained by plotting the relative growth rate versus the chemical concentration which concentrations leading to 50% inhibition of growth (IC50) was determined.Results: the results showed a concentration - dependent cytoxicity effect for SAFF FLOWER extract (IC50=1121 mml-1) and PEGANUM HARMALA extract (IC50=476 mgml-1).The TOXICITY effects of dihidropyridine derivatives was studied up to 100 mMml-1, but no cytotoxic effect was observed.Conclusion: these results were agreement with other cytotoxic tests (Le, rat, hamster, brin shrimp, and human cell cultures) then this procedure can be used as the first step, for assaying acute TOXICITY of chemical substances.

Cites

PHYSICOCHEMICAL PROPERTIES OF IRANIAN VARIETIES/LINES OF SAFFLOWER OIL AND SEED AS A RICH SOURCE OF ω-6

References

ارزیابی آزمون مخمر جهت تعیین سمیت حاد مواد

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APA: Copy

DARABI, N., FALAHATI, M., & MAHMOUDIAN, M.. (2007). EVALUATION OF TOXICITY CHEMICAL SUBSTANCES (EXTRACT OIHYNDROPYRIDINE DERIVATIVES, SAFF FLOWER AND PEGANUM HARMALA) BY SACCHAROMYCES CEREVISIAE. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 5(1 (SERIAL NUMBER 17)), 1111-1114. SID. https://sid.ir/paper/96499/en

Vancouver: Copy

DARABI N., FALAHATI M., MAHMOUDIAN M.. EVALUATION OF TOXICITY CHEMICAL SUBSTANCES (EXTRACT OIHYNDROPYRIDINE DERIVATIVES, SAFF FLOWER AND PEGANUM HARMALA) BY SACCHAROMYCES CEREVISIAE. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2007;5(1 (SERIAL NUMBER 17)):1111-1114. Available from: https://sid.ir/paper/96499/en

IEEE: Copy

N. DARABI, M. FALAHATI, and M. MAHMOUDIAN, “EVALUATION OF TOXICITY CHEMICAL SUBSTANCES (EXTRACT OIHYNDROPYRIDINE DERIVATIVES, SAFF FLOWER AND PEGANUM HARMALA) BY SACCHAROMYCES CEREVISIAE,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 5, no. 1 (SERIAL NUMBER 17), pp. 1111–1114, 2007, [Online]. Available: https://sid.ir/paper/96499/en

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