The Efficacy of Levofloxacin versus Clarithromycin in Primary Quadruple Therapy for the Eradication of Helicobacter Pylori: A Prospective Randomized Controlled Clinical Trial Study

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SEBGHATOLLAHI VAHID; HOSSEINI REYHANEH; TAMIZIFAR BABAK; MINAKARI MOHAMMAD; Soheilipour Maryam

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Journal: Journal of Isfahan Medical School Year:2020 | Volume:38 | Issue:569 Page(s): 186-192

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Title

The Efficacy of Levofloxacin versus Clarithromycin in Primary Quadruple Therapy for the Eradication of Helicobacter Pylori: A Prospective Randomized Controlled Clinical Trial Study

Author(s)

Keywords

Helicobacter pylori

Clarithromycin

Levofloxacin

Abstract

Background: Helicobacter pylori (H. pylori) infection is prevalent in the world. Resistance to antibiotics is the main reason for treatment failure. This clinical trial examined the effect of Clarithromycin versus Levofloxacin as the content of first line of treatment of the patients with peptic ulcer. Methods: In this double-blind randomized controlled clinical trial study with parallel groups, 148 infected patients by H. pylori who had been proven during endoscopic biopsy were randomly divided into two equal groups. One group was treated with the quadruple therapy of Clarithromycin 500 mg BID, amoxicillin 1 g BID, bismuth subcitrate 240 mg BID, and pantazole 40 mg BID. The second group was treated with Levofloxacin 500 mg QD, amoxicillin 1 g BID, bismuth subcitrate 240 mg BID, and pantazole 40 mg BID. The duration of treatment was 14 days in both groups and four weeks after treatment, the eradication rate was assessed using the stool antigen test. Findings: The eradication rate was significantly higher using regime containing Clarithromycin than that of Levofloxacin [81. 1%; confidence interval of 95% (95%CI): 72. 2%-89. 9% vs. 60. 3%; 95%CI: 49. 3%-72. 2%; P = 0. 021). The improvement in quality of life in patients treated with Clarithromycin was comparable with Levofloxacin (7. 90 ± 5. 79 vs. 9. 27 ± 5. 89; P = 0. 18). Adverse effects were different between the groups in which bad taste was reported more frequently in Clarithromycin than Levofloxacin (27. 0% vs. 4. 3%) while epigastric pain was more in Levofloxacin (7. 1% vs. 2. 7%). Conclusion: The effectiveness of Clarithromycin on H. pylori eradication rate was significantly higher than Levofloxacin.

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APA: Copy

SEBGHATOLLAHI, VAHID, HOSSEINI, REYHANEH, TAMIZIFAR, BABAK, MINAKARI, MOHAMMAD, & Soheilipour, Maryam. (2020). The Efficacy of Levofloxacin versus Clarithromycin in Primary Quadruple Therapy for the Eradication of Helicobacter Pylori: A Prospective Randomized Controlled Clinical Trial Study. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 38(569 ), 186-192. SID. https://sid.ir/paper/965136/en

Vancouver: Copy

SEBGHATOLLAHI VAHID, HOSSEINI REYHANEH, TAMIZIFAR BABAK, MINAKARI MOHAMMAD, Soheilipour Maryam. The Efficacy of Levofloxacin versus Clarithromycin in Primary Quadruple Therapy for the Eradication of Helicobacter Pylori: A Prospective Randomized Controlled Clinical Trial Study. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2020;38(569 ):186-192. Available from: https://sid.ir/paper/965136/en

IEEE: Copy

VAHID SEBGHATOLLAHI, REYHANEH HOSSEINI, BABAK TAMIZIFAR, MOHAMMAD MINAKARI, and Maryam Soheilipour, “The Efficacy of Levofloxacin versus Clarithromycin in Primary Quadruple Therapy for the Eradication of Helicobacter Pylori: A Prospective Randomized Controlled Clinical Trial Study,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 38, no. 569 , pp. 186–192, 2020, [Online]. Available: https://sid.ir/paper/965136/en

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