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Information Journal Paper

Title

Autophagy and Apoptosis Crosstalk in Hepatocellular Carcinoma Progression

Pages

  421-433

Abstract

 Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the third cause of cancer-related death worldwide based on a recent update of Globocan in 2020. The induction of programmed cell death (Apoptosis) in tumor cells is one of the main targets of conventional therapies in cancer. One of the key mechanisms that impacts tumor cells apoptotic response is Autophagy. Autophagy is a conserved lysosomedependent degradation process that aids in the maintenance of cell homeostasis and metabolic compatibility. Apoptosis and Autophagy are two main processes in controlling cell death and survival. Enhanced Autophagy at various stages of HCC is related to increased tumor cells survival and malignancy development, allowing cancer cells to evade Apoptosis. Various studies that investigated the effect of Autophagy inhibition on Apoptosis induction in HCC cells indicated that Apoptosis inducers have a stronger therapeutic impact after Autophagy inhibition. In this study, the crosstalk between Autophagy and Apoptosis in cells survival, as well as targeted alterations in the balance between these processes in HCC therapy are investigated.

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    APA: Copy

    Seydi, Homeyra, Torabi, Shukoofeh, Ramezankhani, Roya, Shokoohian, Bahareh, SHEKARI, FAEZEH, & VOSOUGH, MASSOUD. (2021). Autophagy and Apoptosis Crosstalk in Hepatocellular Carcinoma Progression. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 39(628 ), 421-433. SID. https://sid.ir/paper/965199/en

    Vancouver: Copy

    Seydi Homeyra, Torabi Shukoofeh, Ramezankhani Roya, Shokoohian Bahareh, SHEKARI FAEZEH, VOSOUGH MASSOUD. Autophagy and Apoptosis Crosstalk in Hepatocellular Carcinoma Progression. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2021;39(628 ):421-433. Available from: https://sid.ir/paper/965199/en

    IEEE: Copy

    Homeyra Seydi, Shukoofeh Torabi, Roya Ramezankhani, Bahareh Shokoohian, FAEZEH SHEKARI, and MASSOUD VOSOUGH, “Autophagy and Apoptosis Crosstalk in Hepatocellular Carcinoma Progression,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 39, no. 628 , pp. 421–433, 2021, [Online]. Available: https://sid.ir/paper/965199/en

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