Protective effect of ghrelin on histopathological alterations in renal tissue of mice treated with cyclophosphamide

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Abdolahzadeh Haniyeh; Khoshdel Fatemeh; Ashory Fatemeh; VAHEDI PARVIZ; Salimnejad Ramin

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Journal: DANESHVAR MEDICINE Year:2021 | Volume:29 | Issue:153 Page(s): 1-11

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Title

Protective effect of ghrelin on histopathological alterations in renal tissue of mice treated with cyclophosphamide

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Keywords

Cyclophosphamide

Ghrelin

Kidney

Mice

Abstract

Background and Objective: Cyclophosphamide is one of the common medications in chemotherapy and suppression of the immune system in organ transplantation. The clinical use of Cyclophosphamide has been reduced due to its many side effects due to reproductive, hepatic, renal, and cardiac toxicity in patients and animal models. This study aimed to evaluate the effect of Ghrelin against Cyclophosphamide-induced damage to renal tissue. Materials and Methods: Thirty-two (2-month old) male Mice were randomly divided into 4 groups: 1) control 2) Cyclophosphamide 3) Cyclophosphamide + Ghrelin 4) Ghrelin. Cyclophosphamide once a week (100 mg/kg) and Ghrelin (80 μ g/kg) were injected intraperitoneally daily for 5 weeks. After 5 weeks, the Kidneys were removed and after weighing, tissue alterations were examined by hematoxylin-eosin and Periodic Acid Schiff staining. Results: Findings showed that Cyclophosphamide significantly reduces body weight and Kidney weight and also significantly increases tissue damage (p<0. 05). Ghrelin treatment significantly improved the above parameters (p<0. 05). Conclusion: The results of this study showed that Ghrelin can reduce the destructive effects of Cyclophosphamide in renal tissue.

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APA: Copy

Abdolahzadeh, Haniyeh, Khoshdel, Fatemeh, Ashory, Fatemeh, VAHEDI, PARVIZ, & Salimnejad, Ramin. (2021). Protective effect of ghrelin on histopathological alterations in renal tissue of mice treated with cyclophosphamide. DANESHVAR MEDICINE, 29(153 ), 1-11. SID. https://sid.ir/paper/965221/en

Vancouver: Copy

Abdolahzadeh Haniyeh, Khoshdel Fatemeh, Ashory Fatemeh, VAHEDI PARVIZ, Salimnejad Ramin. Protective effect of ghrelin on histopathological alterations in renal tissue of mice treated with cyclophosphamide. DANESHVAR MEDICINE[Internet]. 2021;29(153 ):1-11. Available from: https://sid.ir/paper/965221/en

IEEE: Copy

Haniyeh Abdolahzadeh, Fatemeh Khoshdel, Fatemeh Ashory, PARVIZ VAHEDI, and Ramin Salimnejad, “Protective effect of ghrelin on histopathological alterations in renal tissue of mice treated with cyclophosphamide,” DANESHVAR MEDICINE, vol. 29, no. 153 , pp. 1–11, 2021, [Online]. Available: https://sid.ir/paper/965221/en

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