THE STATUS OF CYTOKERATIN 7 EXPRESSION IN PRIMARY BREAST CANCER AND IT'S RELATIONSHIP WITH PROGNOSTIC FACTORS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JALALI NADOUSHAN M.R.; DAVATI A.; GHARAH GOZ LOUEI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Annals of Military and Health Sciences Research Year:2007 | Volume:5 | Issue:2 (SERIAL NUMBER18) Page(s): 1217-1221

Download Full-Text

Persian Verion

View:

3,189

Download:

Cites:

Information Journal Paper

Title

THE STATUS OF CYTOKERATIN 7 EXPRESSION IN PRIMARY BREAST CANCER AND IT'S RELATIONSHIP WITH PROGNOSTIC FACTORS

Author(s)

JALALI NADOUSHAN M.R. | DAVATI A. | GHARAH GOZ LOUEI M. | Issue Writer Certificate

Keywords

BREAST CANCERQ3

CYTOKERATIN 7Q2

GRADEQ3

STAGEQ3

Abstract

Background: BREAST CANCER is the most common malignancy in women. Some biologic markers are used for determination of prognosis and prediction of treatment response. CYTOKERATIN 7 (CK7) is an Intermediate filament protein of epithelial cells. The purpose of this study is to determine the expression of CYTOKERATIN 7 in primary BREAST CANCER and it's correlation with GRADE, STAGE and axillary lymphnode involvement.Materials and Methods: This was a cross-sectional study performed on 75 samples of patients with BREAST CANCER admitted in Mostafa Khomeini Hosptial (2000-2005). After preparing the samples, a tissue section from each sample was obtained. One of the tumoral sections and one of the lymphnode sections were stained by H & E. We determined the type of the tumor, the number of lymphnodes, the STAGE and the GRADE of the tumor. We studied CYTOKERATIN 7 with monocolonal antibady by IHC.Results: Our study showed that 93.3% of samples were positive for CYTOKERATIN 7. 70.7% of patients had lymphnod involvement, 57.3% of samples were in STAGE 11and the most of patients (42.7%) were in GRADE 11.In this study, we found significant relation between CYTOKERATIN 7 and lymphnode involvement (P=0.002), lymphnode number (P=0.004) and STAGE (P=0.002). We didn't find any relationship between CK7 and GRADE.Conclusion: According to he results of previous studies and our study, it seems that CYTOKERATIN 7 is a prognostic factor in BREAST CANCER. But further investigations with more specimens and long-time follow- p are required to clarify the exact role of CYTOKERATIN 7 in prognosis of BREAST CANCER.

Cites

No record.

References

Cite

APA: Copy

JALALI NADOUSHAN, M.R., DAVATI, A., & GHARAH GOZ LOUEI, M.. (2007). THE STATUS OF CYTOKERATIN 7 EXPRESSION IN PRIMARY BREAST CANCER AND IT'S RELATIONSHIP WITH PROGNOSTIC FACTORS. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 5(2 (SERIAL NUMBER18)), 1217-1221. SID. https://sid.ir/paper/96537/en

Vancouver: Copy

JALALI NADOUSHAN M.R., DAVATI A., GHARAH GOZ LOUEI M.. THE STATUS OF CYTOKERATIN 7 EXPRESSION IN PRIMARY BREAST CANCER AND IT'S RELATIONSHIP WITH PROGNOSTIC FACTORS. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2007;5(2 (SERIAL NUMBER18)):1217-1221. Available from: https://sid.ir/paper/96537/en

IEEE: Copy

M.R. JALALI NADOUSHAN, A. DAVATI, and M. GHARAH GOZ LOUEI, “THE STATUS OF CYTOKERATIN 7 EXPRESSION IN PRIMARY BREAST CANCER AND IT'S RELATIONSHIP WITH PROGNOSTIC FACTORS,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 5, no. 2 (SERIAL NUMBER18), pp. 1217–1221, 2007, [Online]. Available: https://sid.ir/paper/96537/en

Related Journal Papers