The Effect of Eight Weeks of Royal Jelly Consumption on Some of Apoptotic Indicators in Trimethyltin-Induced Alzheimer's Mice

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AZIMPOUR MARYAM; FATHI MOHAMMAD; Dezfulian Omid

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Journal Paper

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Journal: Armaghane Danesh Year:2021 | Volume:26 | Issue:3 (146) Page(s): 307-323

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Information Journal Paper

Title

The Effect of Eight Weeks of Royal Jelly Consumption on Some of Apoptotic Indicators in Trimethyltin-Induced Alzheimer's Mice

Author(s)

AZIMPOUR MARYAM | FATHI MOHAMMAD | Dezfulian Omid | Issue Writer Certificate

Keywords

Royal Jelly

Apoptosis Indicators

Alzheimer's Disease

Abstract

Background & aim: Given that Royal Jelly contains compounds that have beneficial effects on the central nervous system and neural functions, therefore, the aim of this study was to determine and evaluate the effect of Royal Jelly consumption on apoptotic indices in trimethyltin model of Alzheimer's Disease. Methods: In the present experimental study conducted in fall of 2018, 32 male Sprague-Dawley rats were included in the study. Twenty-four of them were induced by Alzheimer's induction by trimethyltin. The rats were then randomly divided into four groups: healthy last week, victim control last week, sham and Royal Jelly. The expression of P53, BAX, BCL-2 genes were measured by Real Time PCR technique. Data analysis was performed by Manova test and post hoc Scheffe at the significant level P<0. 05 using SPSS software version 20. Results: The findings of the present study indicated that the dependent variable P53 in the last week Alzheimer's group was more than the healthy groups in the last week and gel. Moreover, the dependent variable P53 in the sham group was more than the healthy groups in the last week and the gel. In the healthy group, the last week was less than sham and Alzheimer's last week. BCL-2 in the gel group was more than sham and healthy last week and Alzheimer's last week and in the healthy group last week was more than sham and Alzheimer's last week. Conclusion: Trimethylmethine administration may be involved in selective neuronal death and mitochondrial apoptotic pathways in neurodegenerative disorders, and Royal Jelly supplementation may be used as an inhibitor of the internal pathway of apoptosis and to enhance neural function and neuronal regeneration in the present model.

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APA: Copy

AZIMPOUR, MARYAM, FATHI, MOHAMMAD, & Dezfulian, Omid. (2021). The Effect of Eight Weeks of Royal Jelly Consumption on Some of Apoptotic Indicators in Trimethyltin-Induced Alzheimer's Mice. ARMAGHAN DANESH, 26(3 (146) ), 307-323. SID. https://sid.ir/paper/965781/en

Vancouver: Copy

AZIMPOUR MARYAM, FATHI MOHAMMAD, Dezfulian Omid. The Effect of Eight Weeks of Royal Jelly Consumption on Some of Apoptotic Indicators in Trimethyltin-Induced Alzheimer's Mice. ARMAGHAN DANESH[Internet]. 2021;26(3 (146) ):307-323. Available from: https://sid.ir/paper/965781/en

IEEE: Copy

MARYAM AZIMPOUR, MOHAMMAD FATHI, and Omid Dezfulian, “The Effect of Eight Weeks of Royal Jelly Consumption on Some of Apoptotic Indicators in Trimethyltin-Induced Alzheimer's Mice,” ARMAGHAN DANESH, vol. 26, no. 3 (146) , pp. 307–323, 2021, [Online]. Available: https://sid.ir/paper/965781/en

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