INTERACTION EFFECT OF STANOZOLOL AND ENDURANCE TRAINING ON OXIDANT AND ANTIOXIDANT CAPACITY IN LIVER TISSUE OF HEALTHY MALE WISTAR RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Rozbehi Mehrnaz; GAEINI ABBASALI; NOURI REZA; KORDI MOHAMMAD REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Studies in Medical Sciences Year:2019 | Volume:30 | Issue:7 Page(s): 537-547

Download Full-Text

Persian Verion

View:

118

Download:

Cites:

Information Journal Paper

Title

INTERACTION EFFECT OF STANOZOLOL AND ENDURANCE TRAINING ON OXIDANT AND ANTIOXIDANT CAPACITY IN LIVER TISSUE OF HEALTHY MALE WISTAR RATS

Author(s)

Rozbehi Mehrnaz | GAEINI ABBASALI | NOURI REZA | KORDI MOHAMMAD REZA | Issue Writer Certificate

Keywords

Anabolic androgenic steroids

Anti-oxidant

Malondialdehyde

Endurance training

Abstract

Background & Aims: The purpose of this study was to investigate the interaction effect of Endurance training and stanozolol (high dose) on gene expression and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in liver tissue of healthy male Wistar rats. Materials & Methods: Forty male Wistar rats (12-weeks old weighing 289 ± 16 gr) were randomly divided into 4-groups: control (n=10), Endurance training (n=10), Endurance training+ stanozolol (n=10), and stanozolol (n=10). Endurance training+ stanozolol and stanozolol groups received a weekly intramuscular injection (5mg/kg of body weight) of stanozolol. Endurance training+ stanozolol and Endurance training groups were submitted to a progressive running program on a treadmill, for 6 weeks and 5 days per week with 70-75% of VO2max. The content protein of SOD and GPX in liver tissue were measured by ELISA and SOD and GPX mRNA were measured by RT-PCR method. Data were analyzed by one way ANOVA test and statistical significance was defined as P<0. 05. Results: The results showed that SOD mRNA expression in stanozolol group increased significantly Compared to control, Endurance training (P<0. 001), and Endurance training+ stanozolol (P<0. 01). In addition, SOD mRNA expression in Endurance training+ stanozolol increased significantly compared to the control and Endurance training (P<0. 01). GPX mRNA expression and activity enzyme of GPX in Endurance training+ stanozolol increased significantly compared to stanozolol group (P<0. 05). The activity enzyme of SOD in stanozolol, Endurance training, and Endurance training+ stanozolol increased significantly compared to the control group (P<0. 001). The content of liver tissue Malondialdehyde in stanozolol group also increased significantly compared to other groups (P<0. 001). Conclusion: It seems that injection of stanozolol increased both of SOD, GPX, and Malondialdehyde. Whereas Endurance training decreased oxidant effects of stanozolol.

Cites

No record.

References

No record.

Cite

APA: Copy

Rozbehi, Mehrnaz, GAEINI, ABBASALI, NOURI, REZA, & KORDI, MOHAMMAD REZA. (2019). INTERACTION EFFECT OF STANOZOLOL AND ENDURANCE TRAINING ON OXIDANT AND ANTIOXIDANT CAPACITY IN LIVER TISSUE OF HEALTHY MALE WISTAR RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 30(7 ), 537-547. SID. https://sid.ir/paper/965974/en

Vancouver: Copy

Rozbehi Mehrnaz, GAEINI ABBASALI, NOURI REZA, KORDI MOHAMMAD REZA. INTERACTION EFFECT OF STANOZOLOL AND ENDURANCE TRAINING ON OXIDANT AND ANTIOXIDANT CAPACITY IN LIVER TISSUE OF HEALTHY MALE WISTAR RATS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2019;30(7 ):537-547. Available from: https://sid.ir/paper/965974/en

IEEE: Copy

Mehrnaz Rozbehi, ABBASALI GAEINI, REZA NOURI, and MOHAMMAD REZA KORDI, “INTERACTION EFFECT OF STANOZOLOL AND ENDURANCE TRAINING ON OXIDANT AND ANTIOXIDANT CAPACITY IN LIVER TISSUE OF HEALTHY MALE WISTAR RATS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 30, no. 7 , pp. 537–547, 2019, [Online]. Available: https://sid.ir/paper/965974/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops