Effect of Eight Weeks of Resistance Training on Myostatin and Folistatin Proteins Content in Gastrocnemius Muscle Tissue of Elderly Rats

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Asadpour Seyed Moslem; DARYANOOSH FARHAD; SALESI MOHSEN; NEMATI JAVAD

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Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2021 | Volume:28 | Issue:10 Page(s): 3134-3143

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Information Journal Paper

Title

Effect of Eight Weeks of Resistance Training on Myostatin and Folistatin Proteins Content in Gastrocnemius Muscle Tissue of Elderly Rats

Author(s)

Asadpour Seyed Moslem | DARYANOOSH FARHAD | SALESI MOHSEN | NEMATI JAVAD | Issue Writer Certificate

Keywords

Aging

Follistatin Protein

Gastrocnemius Muscle

Myostatin Protein

Resistance Training

Abstract

Introdution: Myostatin and Follistatin Proteins are key proteins in the regulation of muscle atrophy and hypertrophy. Aging and sarcopenia can lead to disruption of cellular mechanisms and the activity of these proteins. Therefore, the aim of the present study was to investigate the effect of eight weeks of Resistance Training on myostatin and folistatin proteins content in Gastrocnemius Muscle tissue of elderly rats. Methods: In this experimental study, 12 female Sprague-Dawley rats (20-month-old) with an average weight of 250± 30 g were selected and randomly divided into 2 groups: Resistance Training (n=6) and control (n=6). The resistance-training program was as followed: 3 days a week for 8 weeks, climbing a one-meter vertical ladder with 26 steps and two centimeters of space between each step with a slope of 85 degrees. SPSS software version 23 and independent t-test were used to analyze the data. Results: The results showed that eight weeks of Resistance Training led to a significant increase in Myostatin Protein content in the training group compared to the control group (P≤ 0. 04). In contrast, eight weeks of Resistance Training led to a significant reduction in folistatin protein content in the training group compared to the control group (P≤ 0. 05). Conclusion: According to the results of the present study on the content of myostatin and folistatin proteins, it is possible that the reduction of muscle atrophy in the elderly can be through other pathways of protein synthesis and muscle hypertrophy.

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APA: Copy

Asadpour, Seyed Moslem, DARYANOOSH, FARHAD, SALESI, MOHSEN, & NEMATI, JAVAD. (2021). Effect of Eight Weeks of Resistance Training on Myostatin and Folistatin Proteins Content in Gastrocnemius Muscle Tissue of Elderly Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 28(10 ), 3134-3143. SID. https://sid.ir/paper/966411/en

Vancouver: Copy

Asadpour Seyed Moslem, DARYANOOSH FARHAD, SALESI MOHSEN, NEMATI JAVAD. Effect of Eight Weeks of Resistance Training on Myostatin and Folistatin Proteins Content in Gastrocnemius Muscle Tissue of Elderly Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(10 ):3134-3143. Available from: https://sid.ir/paper/966411/en

IEEE: Copy

Seyed Moslem Asadpour, FARHAD DARYANOOSH, MOHSEN SALESI, and JAVAD NEMATI, “Effect of Eight Weeks of Resistance Training on Myostatin and Folistatin Proteins Content in Gastrocnemius Muscle Tissue of Elderly Rats,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 10 , pp. 3134–3143, 2021, [Online]. Available: https://sid.ir/paper/966411/en

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