CANCEROUS CELLS DESTRUCTION USING CONCENTRATED ULTRASONIC WAVES ON THREE DIMENSIONAL MODEL OF BREAST TISSUES

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BEHNIA S.; GHALICHI F.

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Journal: IRANIAN JOURNAL OF MEDICAL PHYSICS Year:2005 | Volume:2 | Issue:6 Page(s): 45-51

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Title

CANCEROUS CELLS DESTRUCTION USING CONCENTRATED ULTRASONIC WAVES ON THREE DIMENSIONAL MODEL OF BREAST TISSUES

Author(s)

BEHNIA S. | GHALICHI F. | Issue Writer Certificate

Keywords

NON-INVASIVE CANCER TREATMENTQ4

BREAST CANCERQ2

ULTRASOUND THERMOTHERAPYQ3

Abstract

Introduction: BREAST CANCER is the most frequently diagnosed cancer in women worldwide and there are approximately one million new cases annually. The treatment of BREAST CANCER has shifted away from mastectomy and towards removing just the cancer leaving the normal breast tissue intact. Clinical impetus and justification for pursuing less invasive therapies to improve cosmetics have derived from success of breast conservation therapy in combination with adjuvant treatment modalities, such as radiotherapy, chemotherapy and hormonal therapy since the 1970. Applying ultrasonic waves is one of the non-invasive methods for treatment of cancer. In this method a transducer which is consisted of piezoelectric cells focuses the ultrasonic waves to a focal point. The absorbed energy changes to heat and destroys the cancerous tissue.Method and Materials: In the present paper, several parameters and methods of focusing ultrasonic waves in order to apply hyperthermia cancer therapy has been studied. Also a transducer capable of focusing waves on cancerous tissues with the aid of its piezoelectric-elements is introduced. The amount of absorbed energy was computed by solving numerically the acoustic pressure equation using Rayleigh-Summerfield Integral, with the intention to determine the optimum spatial array of piezoelectric elements for energy concentration. In order to control the treatment procedure, the numerical solution of Bio-heat Transfer Equation [BHTE], along with the finite-element simulation of thermal energy distribution in a BREAST CANCERous tissue is considered. A three-dimensional finite element model for the study of temperature distribution in cancerous tissues of breast is presented. The temperature distribution in the BREAST CANCERous tissues has been calculated and discussed.Results: Assuming the heat source at the center of the tumor location, the bioheat equation was solved for the model. Results showed that using the frequencies in the range of 470-520 kHz could produce enough power to raise the temperature of the focal point up to 45 degrees of centigrade. Also it is seen that the focal area where the peak: temperature is obtained is small so it this method has the ability to kill small tumors at early stages. Also, spatial distribution of the acoustic pressure indicates that the maximum amount of energy is concentrated in the focal zone. An increase in the number of piezoelectric elements will raise the amount of absorbed energy in the target zone and nearby tissues as well.Conclusions: Thermal treatment process modeling has been done using Pennes's bioheat transfer equation. Temperature distribution and the process of temperature rise in the focal region with time and distance is presented. The exact calculation of blood perfusion rate in the target tissue should be considered in the future studies.

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APA: Copy

BEHNIA, S., & GHALICHI, F.. (2005). CANCEROUS CELLS DESTRUCTION USING CONCENTRATED ULTRASONIC WAVES ON THREE DIMENSIONAL MODEL OF BREAST TISSUES. IRANIAN JOURNAL OF MEDICAL PHYSICS, 2(6), 45-51. SID. https://sid.ir/paper/96911/en

Vancouver: Copy

BEHNIA S., GHALICHI F.. CANCEROUS CELLS DESTRUCTION USING CONCENTRATED ULTRASONIC WAVES ON THREE DIMENSIONAL MODEL OF BREAST TISSUES. IRANIAN JOURNAL OF MEDICAL PHYSICS[Internet]. 2005;2(6):45-51. Available from: https://sid.ir/paper/96911/en

IEEE: Copy

S. BEHNIA, and F. GHALICHI, “CANCEROUS CELLS DESTRUCTION USING CONCENTRATED ULTRASONIC WAVES ON THREE DIMENSIONAL MODEL OF BREAST TISSUES,” IRANIAN JOURNAL OF MEDICAL PHYSICS, vol. 2, no. 6, pp. 45–51, 2005, [Online]. Available: https://sid.ir/paper/96911/en

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