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Information Journal Paper

Title

Clinical and Pharmacological Evaluation of Pistacia atlantica Nut Extract on Septic Arthritis Caused by Staphylococcus aureus: An Experimental Study

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Abstract

 Background: Today, the incidence of septic Arthritis by Staphylococcus aureus has increased due to intra-articular injections, prosthetic joints, and underlying conditions such as rheumatoid Arthritis and immunosuppression. Pistacia atlantica has signifi cant antioxidant, anti-infl ammatory, and antibacterial activities. Objectives: Considering S. aureus as the most important etiology of septic Arthritis, this experimental study aimed to evaluate the eff ects of P. atlantica on septic Arthritis. Methods: Septic Arthritis was induced by intra-articular injection of S. aureus suspension in left stifl es of rats, which were divided randomly into eight groups, containing ten per group, including normal: no intervention; control: septic Arthritis was induced but not treated; Oral Placebo (OP): 14 days daily P. O.; Local Injected Placebo (LIP): a single dose intra-articular (IA injection) of normal saline; Oral P. atlantica (OPa): 14 days daily P. O. P. atlantica extract; Local Injected P. atlantica (LIPa): a single-dose IA injection of P. atlantica extract; Prophylactic Oral P. atlantica (ProOPa): prophylactic P. O. P. atlantica extract daily one week before the induction for 21 days; Prophylactic Local Injected P. atlantica (ProLIPa): a prophylactic single-dose IA injection of P. atlantica extract one week before the induction. For further evaluations, blood and histopathological samples were obtained. Results: Pistacia atlantica oral medication reduced the physical symptoms of infl ammation. Although hematological analysis showed a fall in the control group compared to the normal group, all medicated groups increased. The OPa group showed the closest WBC count (9. 46  4. 12  10 /L) to the normal group (P = 0. 073). All histopathological parameters had signifi cantly higher scores in the control group compared to the normal group. Although the scores increased in the groups that received P. atlantica, they decreased in the groups that received placebo, except for synovitis degree. The OPa group demonstrated a lower degree of synovitis (1. 40  0. 51) than the control group; however, it was not signifi cant (P = 0. 690). Local injections revealed higher erosion scores (2. 80  0. 63 for the LIPa group and 2. 70  0. 48 for the ProLIPa group) than the control group (P < 0. 05). Conclusions: Oral administration of P. atlantica alleviated the Clinical symptoms. Cellular Immunity activation and systemic benefi ts of oral P. atlantica were assessed. HistoPathology confi rmed the immune system involvement and antibacterial activity of P. atlantica. More erosion may be due to more bacterial debris with arthritogenic properties. Meanwhile, the probability of the stimulatory eff ect of P. atlantica extract for synovial content should not be ignored.

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    APA: Copy

    NAMAZI, HAMID, EMAMI, MOHAMMAD JAFAR, Dehghani Nazhvani, Fatemeh, NAZIFI, SAEED, DEHGHANIAN, AMIRREZA, & KAZEMI MOGHADDAM, EHSAN. (2020). Clinical and Pharmacological Evaluation of Pistacia atlantica Nut Extract on Septic Arthritis Caused by Staphylococcus aureus: An Experimental Study. SHIRAZ E MEDICAL JOURNAL, 21(11), 0-0. SID. https://sid.ir/paper/969517/en

    Vancouver: Copy

    NAMAZI HAMID, EMAMI MOHAMMAD JAFAR, Dehghani Nazhvani Fatemeh, NAZIFI SAEED, DEHGHANIAN AMIRREZA, KAZEMI MOGHADDAM EHSAN. Clinical and Pharmacological Evaluation of Pistacia atlantica Nut Extract on Septic Arthritis Caused by Staphylococcus aureus: An Experimental Study. SHIRAZ E MEDICAL JOURNAL[Internet]. 2020;21(11):0-0. Available from: https://sid.ir/paper/969517/en

    IEEE: Copy

    HAMID NAMAZI, MOHAMMAD JAFAR EMAMI, Fatemeh Dehghani Nazhvani, SAEED NAZIFI, AMIRREZA DEHGHANIAN, and EHSAN KAZEMI MOGHADDAM, “Clinical and Pharmacological Evaluation of Pistacia atlantica Nut Extract on Septic Arthritis Caused by Staphylococcus aureus: An Experimental Study,” SHIRAZ E MEDICAL JOURNAL, vol. 21, no. 11, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/969517/en

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