Association of Resistin Gene Polymorphism with Type 2 Diabetes in Khuzestan Province

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MOHAMMADI ASL JAVAD; Azarkish Mehrnoosh; GHANBARI MARDASI FARIDEH; GHAFFARI MOHAMMAD ALI; Reaadeh Mahin

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Journal: Gene, Cell and Tissue Year:2019 | Volume:6 | Issue:4 Page(s): 0-0

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Title

Association of Resistin Gene Polymorphism with Type 2 Diabetes in Khuzestan Province

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Keywords

Resistin Gene

Type 2 Diabetes

Polymorphism

Abstract

Background: Genome-Wide Association Studies (GWAS) have recognized that Polymorphisms of the Resistin Gene were strongly correlated with the risk of Type 2 Diabetes. Objectives: The present study aimed to investigate the association of the-420 Resistin Gene Polymorphism with Type 2 Diabetes in Khuzestan province, Iran. Methods: Unrelated healthy controls (n = 200) and Type 2 Diabetes mellitus (T2DM) patients (n = 200) were selected from Khuzestan province, Iran. Genotyping was performed by the PCR-RFLP method. Results: The frequency of the CC genotype in diabetic patients was about twice as high as in healthy individuals (P < 0. 05). The frequency of the C allele was higher in diabetics than in healthy subjects and this difference was statistically significant. Also, diabetic patients with the CC genotype had the highest fasting blood glucose and the lowest HbA1C among studied patients with other genotypes although these differences were not statistically significant (P 0. 05). Conclusions: The findings showed that the Resistin Gene Polymorphism at position-420 (C>G) gene was correlated with T2DM. In addition, the high frequency of the C allele in diabetic patients may influence susceptibility to T2DM.

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APA: Copy

MOHAMMADI ASL, JAVAD, Azarkish, Mehrnoosh, GHANBARI MARDASI, FARIDEH, GHAFFARI, MOHAMMAD ALI, & Reaadeh, Mahin. (2019). Association of Resistin Gene Polymorphism with Type 2 Diabetes in Khuzestan Province. GENE, CELL AND TISSUE, 6(4), 0-0. SID. https://sid.ir/paper/969640/en

Vancouver: Copy

MOHAMMADI ASL JAVAD, Azarkish Mehrnoosh, GHANBARI MARDASI FARIDEH, GHAFFARI MOHAMMAD ALI, Reaadeh Mahin. Association of Resistin Gene Polymorphism with Type 2 Diabetes in Khuzestan Province. GENE, CELL AND TISSUE[Internet]. 2019;6(4):0-0. Available from: https://sid.ir/paper/969640/en

IEEE: Copy

JAVAD MOHAMMADI ASL, Mehrnoosh Azarkish, FARIDEH GHANBARI MARDASI, MOHAMMAD ALI GHAFFARI, and Mahin Reaadeh, “Association of Resistin Gene Polymorphism with Type 2 Diabetes in Khuzestan Province,” GENE, CELL AND TISSUE, vol. 6, no. 4, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/969640/en

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