Diagnostic value of serum IgG by ELISA to detect Mycobacterium tuberculosis

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Haghdoost mehdi; Alizadeh Nazmi Parisa; OWAYSEE OSQUEE HAMID

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Journal Paper

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Journal: JOURNAL OF RESEARCH IN CLINICAL MEDICINE Year:2021 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Diagnostic value of serum IgG by ELISA to detect Mycobacterium tuberculosis

Author(s)

Haghdoost mehdi | Alizadeh Nazmi Parisa | OWAYSEE OSQUEE HAMID | Issue Writer Certificate

Keywords

Tuberculosis

Sensitivity

Specificity

IgG

Abstract

Introduction: In developing countries, which is an endemic region in terms of Tuberculosis, there is an urgent need for fast, accurate and inexpensive serological tests. The aim of this study was to determine the diagnostic value of serum immunoglobulin G (IgG) antibody by ELISA to detect Mycobacterium Tuberculosis. Method: This study was performed on patients with pulmonary Tuberculosis in 2017-2020. After selecting the 2 case (Pulmonary Tuberculosis and latent Tuberculosis, each had 30 patients, total 60 patients) and control (n = 30) subjects according to inclusion criteria, their blood samples were obtained and analyzed in the reference laboratory by standard kits for IgG against 16, 36 and 40 kDa antigens of Mycobacterium Tuberculosis. Results: The mean age of the subjects was 50. 60 years old. The majority of participants were 46 (51. 1%) women. There was no significant difference between the two groups regarding sex and age. Serological examination of patients with pulmonary Tuberculosis showed 25 positive results and only 4 of the control group had a positive result. Sensitivity, Specificity, positive and negative predictive values of serology test were 83. 3%, 86. 67%, 86. 20%, and 87. 88%, respectively. Conclusion: Despite the acceptable Sensitivity of the serologic IgG test, according to the statement of World health organization (WHO), it did not possess an acceptable Specificity. It is recommended that a wider range of different antigens to be studied. Also, it is essential to evaluate the diagnostic value of the other immunoglobulins in patient in different stages of disease.

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APA: Copy

Haghdoost, mehdi, Alizadeh Nazmi, Parisa, & OWAYSEE OSQUEE, HAMID. (2021). Diagnostic value of serum IgG by ELISA to detect Mycobacterium tuberculosis. JOURNAL OF RESEARCH IN CLINICAL MEDICINE, 9(1), 0-0. SID. https://sid.ir/paper/969722/en

Vancouver: Copy

Haghdoost mehdi, Alizadeh Nazmi Parisa, OWAYSEE OSQUEE HAMID. Diagnostic value of serum IgG by ELISA to detect Mycobacterium tuberculosis. JOURNAL OF RESEARCH IN CLINICAL MEDICINE[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/969722/en

IEEE: Copy

mehdi Haghdoost, Parisa Alizadeh Nazmi, and HAMID OWAYSEE OSQUEE, “Diagnostic value of serum IgG by ELISA to detect Mycobacterium tuberculosis,” JOURNAL OF RESEARCH IN CLINICAL MEDICINE, vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/969722/en

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