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Information Journal Paper

Title

The Interactive Effects of Continuous and Interval Training with Crocin Consumption on the Levels of Interleukin-17 and Interleukin-18 in the Soleus Muscle of Rats with Type II Diabetes

Pages

  160-167

Abstract

 Introduction: Muscle inflammation and atrophy are among the main complications of Diabetes, which lead to motor disability in the patients. Studies have shown that physical exercise with various intensities and use of herbal medicines could positively affect Diabetes. The present study aimed to evaluate the interactive effects of continuous and interval Training with Crocin consumption on the levels of interleukin-17 (IL-17) and interleukin-18 (IL-18) in the soleus muscle of rates with type II Diabetes. Methods: This experimental study was conducted on 49 adult diabetic rats, which were randomly assigned to seven groups, including: high-intensity interval Training (HIIT), low-intensity continuous Training (LICT), HIIT with Crocin consumption, LICT with Crocin consumption, Crocin consumption, sham, and control. The HIIT and LICT groups received Training for eight weeks using a rodent treadmill. The Crocin consumption groups were intraperitoneally administered with Crocin (25 mg/kg) daily for eight weeks. The gene expression levels of IL-17 and IL-18 were measured using real-time polymerase chain reaction (RT-PCR). Results: HIIT increased IL-17 and IL-18 in the soleus muscle tissue of the diabetic rates (P≤ 0. 05), while LICT had no significant effects on the levels of IL-17 and IL-18 (P≥ 0. 05). On the other hand, Crocin consumption decreased the expression of IL-18 and increased the expression of IL-17 in the soleus muscle tissue (P≤ 0. 05), and the interactive effects of LICT and Crocin consumption were considered significant in increasing IL-17 and IL-18 (P≤ 0. 05). Conclusion: According to the results, HIIT may exert inflammatory effects on the muscle tissue of rats with type II Diabetes. However, the interactive effects of LICT and Crocin were significant on increasing IL-17 and IL-18 in the soleus muscle tissue of diabetic rats.

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    APA: Copy

    Moghadas, Najimeh, khajehlandi, Ali, & MOHAMMADI, AMIN. (2019). The Interactive Effects of Continuous and Interval Training with Crocin Consumption on the Levels of Interleukin-17 and Interleukin-18 in the Soleus Muscle of Rats with Type II Diabetes. JOURNAL OF NUTRITION, FASTING AND HEALTH, 7(3), 160-167. SID. https://sid.ir/paper/970909/en

    Vancouver: Copy

    Moghadas Najimeh, khajehlandi Ali, MOHAMMADI AMIN. The Interactive Effects of Continuous and Interval Training with Crocin Consumption on the Levels of Interleukin-17 and Interleukin-18 in the Soleus Muscle of Rats with Type II Diabetes. JOURNAL OF NUTRITION, FASTING AND HEALTH[Internet]. 2019;7(3):160-167. Available from: https://sid.ir/paper/970909/en

    IEEE: Copy

    Najimeh Moghadas, Ali khajehlandi, and AMIN MOHAMMADI, “The Interactive Effects of Continuous and Interval Training with Crocin Consumption on the Levels of Interleukin-17 and Interleukin-18 in the Soleus Muscle of Rats with Type II Diabetes,” JOURNAL OF NUTRITION, FASTING AND HEALTH, vol. 7, no. 3, pp. 160–167, 2019, [Online]. Available: https://sid.ir/paper/970909/en

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