Histomorphometric Effects of 2% Risedronate Gel on Calvarial Bone Defects in Rabbits

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Aghayan Shabnam; ASGHARI AHMAD; MORTAZAVI PEJMAN; Marzoughi Shirin

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Dentistry Year:2021 | Volume:22 | Issue:1 Page(s): 14-20

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Histomorphometric Effects of 2% Risedronate Gel on Calvarial Bone Defects in Rabbits

Author(s)

Aghayan Shabnam | ASGHARI AHMAD | MORTAZAVI PEJMAN | Marzoughi Shirin | Issue Writer Certificate

Keywords

Bone Loss

Osteoclast

Rabbit

Risedronate

Abstract

Statement of the Problem: Alveolar bone resorption associated with periodontal disease is a common finding and generally irreversible. It impairs mastication and causes esthetic problems for patients. Bisphosphonates are the most commonly used antiresorptive agents for bone diseases. Purpose: Considering the risk of bisphosphonate-related osteonecrosis of the jaw, this study aimed to assess the effect of 2% Risedronate gel on calvarial bone defects in Rabbits. Materials and Method: In this animal study, critical-size defects of 8mm were created in the calvaria of 20 New Zealand white Rabbits. In group 1 (n=10), 2% Risedronate gel was applied into the right side defect while the left side defect remained empty and served as control. In group 2 (n=10), placebo gel was applied into the right side defect, while the left side defect remained empty and served as control. Five Rabbits in each group were sacrificed at 1month and the remaining five at 2 month, post-operatively, and tissue samples were collected for histomorphometric analysis. Histomorphometric assessments included bone fill, degree of inflammation, number of osteoblasts, number of Osteoclasts, and foreign body reaction at the site. Data were statistically analysed using SPSS version 25 via the Dunn test and Kruskal-Wallis test. Results: No bone remodeling was noted in any group at 1 month. The Risedronate group showed significantly higher bone fill than the other groups after 2 months (p= 0. 016). At 2 months, the number of osteoblasts was significantly higher in the Risedronate group (p< 0. 05). The groups were not significantly different in terms of inflammation score at 1 (p= 0. 31) or 2 (p=0. 69) months. Foreign body reaction was not observed in any group at any time point. No Osteoclast was detected in any group at any time point. Conclusion: Risedronate gel showed superior efficacy with regard to regeneration of Rabbit calvarial bone defects compared to the placebo and control groups.

Cites

No record.

References

Histomorphometric Comparison of 2 types of FDBA and DFDBA bone powders manufactured by Hamanand Saz Baft Kish Company in treatment of defects in rabbit calvaria bone

Cite

APA: Copy

Aghayan, Shabnam, ASGHARI, AHMAD, MORTAZAVI, PEJMAN, & Marzoughi, Shirin. (2021). Histomorphometric Effects of 2% Risedronate Gel on Calvarial Bone Defects in Rabbits. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 22(1), 14-20. SID. https://sid.ir/paper/974545/en

Vancouver: Copy

Aghayan Shabnam, ASGHARI AHMAD, MORTAZAVI PEJMAN, Marzoughi Shirin. Histomorphometric Effects of 2% Risedronate Gel on Calvarial Bone Defects in Rabbits. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2021;22(1):14-20. Available from: https://sid.ir/paper/974545/en

IEEE: Copy

Shabnam Aghayan, AHMAD ASGHARI, PEJMAN MORTAZAVI, and Shirin Marzoughi, “Histomorphometric Effects of 2% Risedronate Gel on Calvarial Bone Defects in Rabbits,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 22, no. 1, pp. 14–20, 2021, [Online]. Available: https://sid.ir/paper/974545/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops