Effect of Collagen Hydrolysate and Fish Oil on High-Sensitivity C-Reactive Protein and Glucose Homeostasis in Patients with severe Burn; a Randomized Clinical Trial

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ALIPOOR ELHAM; HOSSEINZADEH ATTAR MOHAMMAD JAVAD; SALEHI SHIVA; DAHMARDEHEI MOSTAFA; YASERI MEHDI; EMAMI MOHAMMAD REZA; HAJIAN MEHDI; REZAYAT SEYED MAHDI; JAZAYERI SHIMA

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Journal: Archives of Academic Emergency Medicine Year:2021 | Volume:9 | Issue:1 Page(s): 0-0

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Title

Effect of Collagen Hydrolysate and Fish Oil on High-Sensitivity C-Reactive Protein and Glucose Homeostasis in Patients with severe Burn; a Randomized Clinical Trial

Author(s)

Keywords

Burns

Collagen

Inflammation

Insulin resistance

Fatty Acids

Omega-3

Abstract

Introduction: Collagen and Omega-3 Fatty Acids (FAs) are suggested to have anti-inflammatory, anti-oxidant, and insulin-sensitizing properties. The aim of this study was to investigate the effect of Collagen hydrolysate and Omega-3 FAs on Inflammation and Insulin resistance in patients with major Burns. Methods: In this doubleblind randomized clinical trial, 66 patients with 20-45% Burns were assigned to either of the three groups of Collagen (40 gr/d), Collagen (40 gr/d) plus fish oil (10 ml/d), or control. High-sensitivity C-reactive protein (hs-CRP), fasting blood glucose (FBG) and insulin concentrations, and homeostatic model assessment for Insulin resistance (HOMA-IR) were assessed at baseline, as well as end of weeks two and three. Results: Based on posthoc analyses, hs-CRP levels were significantly lower in the Collagen (p=0. 026) and Collagen+Omega-3 (p=0. 044) groups compared to the control group, at week three. However, pre-to post-(week three) changes of hs-CRP were significantly higher only in the Collagen+Omega-3 group compared to the control group (173. 2 vs. 103. 7 mg/l, p=0. 024). After three weeks of the intervention, insulin (11. 3 and 11. 9 vs. 22. 8 &IU/ml) and HOMA-IR (2. 9 and 2. 8 vs. 7. 9) values seemed to be clinically, but not statistically, lower in both intervention groups compared to the control group. Pre-to post-(week three) values of FBG decreased significantly in the Collagen (p=0. 002) and Collagen+Omega-3 (p=0. 036) groups. Insulin (p=0. 008) andHOMA-IR (p=0. 001) decreased significantly only in the Collagen+Omega-3 group at week three compared to the baseline. Conclusion: Supplementation with Collagen hydrolysate and Omega-3 FAs can improve hs-CRP concentration and probably Insulin resistance in patients with severe Burns. Omega-3 FAs had additional effects on modulating Inflammation. Larger clinical trials are needed to confirmthe current findings especially in terms of glucose homeostasis.

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APA: Copy

ALIPOOR, ELHAM, HOSSEINZADEH ATTAR, MOHAMMAD JAVAD, SALEHI, SHIVA, DAHMARDEHEI, MOSTAFA, YASERI, MEHDI, EMAMI, MOHAMMAD REZA, HAJIAN, MEHDI, REZAYAT, SEYED MAHDI, & JAZAYERI, SHIMA. (2021). Effect of Collagen Hydrolysate and Fish Oil on High-Sensitivity C-Reactive Protein and Glucose Homeostasis in Patients with severe Burn; a Randomized Clinical Trial. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), 9(1), 0-0. SID. https://sid.ir/paper/974728/en

Vancouver: Copy

ALIPOOR ELHAM, HOSSEINZADEH ATTAR MOHAMMAD JAVAD, SALEHI SHIVA, DAHMARDEHEI MOSTAFA, YASERI MEHDI, EMAMI MOHAMMAD REZA, HAJIAN MEHDI, REZAYAT SEYED MAHDI, JAZAYERI SHIMA. Effect of Collagen Hydrolysate and Fish Oil on High-Sensitivity C-Reactive Protein and Glucose Homeostasis in Patients with severe Burn; a Randomized Clinical Trial. ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY)[Internet]. 2021;9(1):0-0. Available from: https://sid.ir/paper/974728/en

IEEE: Copy

ELHAM ALIPOOR, MOHAMMAD JAVAD HOSSEINZADEH ATTAR, SHIVA SALEHI, MOSTAFA DAHMARDEHEI, MEHDI YASERI, MOHAMMAD REZA EMAMI, MEHDI HAJIAN, SEYED MAHDI REZAYAT, and SHIMA JAZAYERI, “Effect of Collagen Hydrolysate and Fish Oil on High-Sensitivity C-Reactive Protein and Glucose Homeostasis in Patients with severe Burn; a Randomized Clinical Trial,” ARCHIVES OF ACADEMIC EMERGENCY MEDICINE (EMERGENCY), vol. 9, no. 1, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/974728/en

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