THE EFFECT OF IMMOBILIZATION STRESS AND INTRAPERITONEAL INJECTION OF DIAZEPAM ON THE FORMALIN-INDUCED PAIN RESPONSE IN MICE

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TAMADONFARD E.; HOSSEIN BOR M.O.; SEYEDNEZHAD SOUNA

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2007 | Volume:3 | Issue:1 (14) Page(s): 28-36

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Title

THE EFFECT OF IMMOBILIZATION STRESS AND INTRAPERITONEAL INJECTION OF DIAZEPAM ON THE FORMALIN-INDUCED PAIN RESPONSE IN MICE

Author(s)

TAMADONFARD E. | HOSSEIN BOR M.O. | SEYEDNEZHAD SOUNA | Issue Writer Certificate

Keywords

STRESSQ3

DIAZEPAMQ3

FORMALIN PAINQ3

MICEQ3

Abstract

This study was designed to investigate the effects of immobilization STRESS and intraperitoneal injection of DIAZEPAM alone before and after STRESS on the formalin induced pain response in MICE. A total of 56 male MICE weighing between 23-25gr was used. Animals were undertaken of immobilization STRESS (30 min). DIAZEPAM (2mg/kg) alone or before and after STRESS was intraperitoneally injected. MICE were placed in the formalin test chambers. Intraplantar injection of formalin (20 ml , 5%) was performed and pain behavior was scored every 15 seconds at five minute intervals for one hour. The results showed that formalin produced a biphasic response (first phase: 0-5 and second pbase: 21-50 min after injection). STRESS and DIAZEPAM, without any effect on the first phase, decreased the second phase of pain (p<0.05). The suppressive effect of DIAZEPAM on the second phase of pain was more intense than that of STRESS. DIAZEPAM, before and after STRESS, decreased the first phase of pain (p<0.05). The suppressive effect of STRESS on the second phase of pain was potentiated by DIAZEPAM. It is concluded that STRESS and DIAZEPAM suppressed the second phase (inflammatory pain) of formalin-induced nociception, and STRESS-induced analgesia was potentiated by DIAZEPAM.

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References

THE EFFECT OF INTRAPERITONEAL INJECTION OF CIMETIDINE ON PAIN RESPONSE INDUCED BY FORMALIN IN MICE

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APA: Copy

TAMADONFARD, E., HOSSEIN BOR, M.O., & SEYEDNEZHAD, SOUNA. (2007). THE EFFECT OF IMMOBILIZATION STRESS AND INTRAPERITONEAL INJECTION OF DIAZEPAM ON THE FORMALIN-INDUCED PAIN RESPONSE IN MICE. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 3(1 (14)), 28-36. SID. https://sid.ir/paper/97482/en

Vancouver: Copy

TAMADONFARD E., HOSSEIN BOR M.O., SEYEDNEZHAD SOUNA. THE EFFECT OF IMMOBILIZATION STRESS AND INTRAPERITONEAL INJECTION OF DIAZEPAM ON THE FORMALIN-INDUCED PAIN RESPONSE IN MICE. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2007;3(1 (14)):28-36. Available from: https://sid.ir/paper/97482/en

IEEE: Copy

E. TAMADONFARD, M.O. HOSSEIN BOR, and SOUNA SEYEDNEZHAD, “THE EFFECT OF IMMOBILIZATION STRESS AND INTRAPERITONEAL INJECTION OF DIAZEPAM ON THE FORMALIN-INDUCED PAIN RESPONSE IN MICE,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 3, no. 1 (14), pp. 28–36, 2007, [Online]. Available: https://sid.ir/paper/97482/en

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