Comparison of Intraperitoneal Bupivacaine and Intravenous Ketorolac for Postoperative Pain Management Following Laparoscopic Cholecystectomy

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Arabzadeh AmirAhmad; SEYEDSADEGHI Mirsalim; Sadeghi Nahideh; Nejati Kazem; MOHAMMADIAN ERDI ALI

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Journal: Anesthesiology and Pain Medicine Year:2021 | Volume:11 | Issue:6 Page(s): 0-0

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Title

Comparison of Intraperitoneal Bupivacaine and Intravenous Ketorolac for Postoperative Pain Management Following Laparoscopic Cholecystectomy

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Keywords

Ketorolac

Bupivacaine

Intraperitoneal Injection

Postoperative Pain

Laparoscopic Cholecystectomy

Abstract

Background: Postoperative Pain following Laparoscopic Cholecystectomy (LC) arises from incision sites and residual intraperitoneal CO2 gas. Opioids as a class of pain-relieving drugs are broadly used to control pain after LC; however, these drugs can cause various side eﬀ ects. Objectives: The purpose of this study was to compare the eﬃ cacy of Intraperitoneal Injection of Bupivacaine with that of intravenous Ketorolac in managing Postoperative Pain in patients who had undergone LC. Methods: This randomized, double-blind clinical trial was carried out on patients who had undergone LC. Ninety patients who had undergone elective LC were randomly divided into 3 groups (n = 30 for each group). Group A received 40 mL of 0. 25% Bupivacaine solution intraperitoneally at the end of the operation; group B received 30 mg of Ketorolac intravenously 30 minutes before surgery and every 8 hours after surgery, and patients in group C received normal saline intraperitoneally and intravenous injection. The patients were postoperatively assessed for Visual Analog Scale (VAS) scores, postoperative opioid consumption, shoulder pain, side eﬀ ects (sedation, nausea, and vomiting), and satisfaction. The data were analyzed using SPSS. P values < 0. 05 were considered signiﬁ cant. Results: The Intraperitoneal Injection of Bupivacaine and intravenous injection of Ketorolac were signiﬁ cantly eﬀ ective in reducing postoperative abdominal pain, shoulder pain, and incidence of nausea and vomiting compared to the placebo group (P < 0. 001). Although intraperitoneal Bupivacaine and intravenous Ketorolac had no signiﬁ cant diﬀ erence in pain relief compared with each other, patients in both Bupivacaine and Ketorolac groups were signiﬁ cantly more satisﬁ ed with their analgesia compared to the control group (P < 0. 001). Conclusions: Intraperitoneal Injection of Bupivacaine and intravenous injection of Ketorolac both are safe and eﬀ ective methods to control pain, nausea, and vomiting after LC.

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APA: Copy

Arabzadeh, AmirAhmad, SEYEDSADEGHI, Mirsalim, Sadeghi, Nahideh, Nejati, Kazem, & MOHAMMADIAN ERDI, ALI. (2021). Comparison of Intraperitoneal Bupivacaine and Intravenous Ketorolac for Postoperative Pain Management Following Laparoscopic Cholecystectomy. ANESTHESIOLOGY AND PAIN MEDICINE, 11(6), 0-0. SID. https://sid.ir/paper/976654/en

Vancouver: Copy

Arabzadeh AmirAhmad, SEYEDSADEGHI Mirsalim, Sadeghi Nahideh, Nejati Kazem, MOHAMMADIAN ERDI ALI. Comparison of Intraperitoneal Bupivacaine and Intravenous Ketorolac for Postoperative Pain Management Following Laparoscopic Cholecystectomy. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2021;11(6):0-0. Available from: https://sid.ir/paper/976654/en

IEEE: Copy

AmirAhmad Arabzadeh, Mirsalim SEYEDSADEGHI, Nahideh Sadeghi, Kazem Nejati, and ALI MOHAMMADIAN ERDI, “Comparison of Intraperitoneal Bupivacaine and Intravenous Ketorolac for Postoperative Pain Management Following Laparoscopic Cholecystectomy,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 11, no. 6, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/976654/en

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