Comparison of Labetalol, Nitroglycerine and High Dose Propofol for Induced Hypotension in Functional Endoscopic Sinus Surgery in Massive Nasal Polyposis: A Randomized Trial

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MIRESKANDARI SEYED MOHAMMAD; MAKAREM JALIL; SAEDI BABAK; JAFARZADEH AFSHIN; KARVANDIAN KASRA; EFTEKHAR NEGAR; SAMADI SHAHRAM; MAJEDI HOSSEIN; AMALI AMIN; Toosi Roja; Naghavi Batool; Vosoughi Fardis

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Journal: Archives of Anesthesiology and Critical Care Year:2020 | Volume:6 | Issue:3 Page(s): 112-117

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Title

Comparison of Labetalol, Nitroglycerine and High Dose Propofol for Induced Hypotension in Functional Endoscopic Sinus Surgery in Massive Nasal Polyposis: A Randomized Trial

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Keywords

Functional endoscopic sinus surgery

Induced hypotension

Labetalol

Nitroglycerine

Propofol

Abstract

Background: The aim of this study was to assess the quality of the surgical field, amount of blood loss, and duration of surgery following Induced hypotension with Labetalol, nitroglycerin, and high dose Propofol in patients undergoing FESS under general anesthesia. Methods: One hundred and eight patients scheduled for FESS under general anesthesia were recruited in this randomized trial and were allocated to one of the three study groups: 1) Nitroglycerine (NTG) group: Nitroglycerine with a dose of 25 μ g/kg/min was administered; 2) Labetalol (LAB) group: an IV bolus dose of Labetalol (20 mg) was injected at first and then IV infusion of Labetalol at a rate of 12 mg/min; 3) High dose Propofol plus normal saline (0. 5-1 ml/min) group. Hemodynamic variables and the amount of bleeding were recorded intraoperatively and the surgeons' satisfaction was asked following each surgery considering the surgical field quality using a 5-item Likert scale. Results: The average blood loss (ml) in patients in the LAB group was significantly less than patients in NTG and high dose Propofol groups (127 ml vs 198 and 145 ml, respectively) (p-value=0. 001) and the surgeons expressed greater satisfaction with the surgical field quality in the LAB group (p-value=0. 001). Conclusion: Labetalol infusion may be a safe and effective method for induction of controlled hypotension to provide a comparatively bloodless field. High dose Propofol may be a second choice if Labetalol is not available.

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APA: Copy

MIRESKANDARI, SEYED MOHAMMAD, MAKAREM, JALIL, SAEDI, BABAK, JAFARZADEH, AFSHIN, KARVANDIAN, KASRA, EFTEKHAR, NEGAR, SAMADI, SHAHRAM, MAJEDI, HOSSEIN, AMALI, AMIN, Toosi, Roja, Naghavi, Batool, & Vosoughi, Fardis. (2020). Comparison of Labetalol, Nitroglycerine and High Dose Propofol for Induced Hypotension in Functional Endoscopic Sinus Surgery in Massive Nasal Polyposis: A Randomized Trial. ARCHIVES OF ANESTHESIOLOGY AND CRITICAL CARE, 6(3), 112-117. SID. https://sid.ir/paper/977620/en

Vancouver: Copy

MIRESKANDARI SEYED MOHAMMAD, MAKAREM JALIL, SAEDI BABAK, JAFARZADEH AFSHIN, KARVANDIAN KASRA, EFTEKHAR NEGAR, SAMADI SHAHRAM, MAJEDI HOSSEIN, AMALI AMIN, Toosi Roja, Naghavi Batool, Vosoughi Fardis. Comparison of Labetalol, Nitroglycerine and High Dose Propofol for Induced Hypotension in Functional Endoscopic Sinus Surgery in Massive Nasal Polyposis: A Randomized Trial. ARCHIVES OF ANESTHESIOLOGY AND CRITICAL CARE[Internet]. 2020;6(3):112-117. Available from: https://sid.ir/paper/977620/en

IEEE: Copy

SEYED MOHAMMAD MIRESKANDARI, JALIL MAKAREM, BABAK SAEDI, AFSHIN JAFARZADEH, KASRA KARVANDIAN, NEGAR EFTEKHAR, SHAHRAM SAMADI, HOSSEIN MAJEDI, AMIN AMALI, Roja Toosi, Batool Naghavi, and Fardis Vosoughi, “Comparison of Labetalol, Nitroglycerine and High Dose Propofol for Induced Hypotension in Functional Endoscopic Sinus Surgery in Massive Nasal Polyposis: A Randomized Trial,” ARCHIVES OF ANESTHESIOLOGY AND CRITICAL CARE, vol. 6, no. 3, pp. 112–117, 2020, [Online]. Available: https://sid.ir/paper/977620/en

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