Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARIFI AMROLLAH; VAHEDI HOMAYOON; HONARVAR MOHAMMAD REZA; ALIPOOR BEHNAM; NIKNIAZ ZEINAB; RAFIEI HOSSEIN; HOSSEINZADEH ATTAR MOHAMMAD JAVAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD) Year:2019 | Volume:11 | Issue:4 Page(s): 199-204

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis

Author(s)

Keywords

Ulcerative Colitis

Inflammatory Bowel Disease

CTLA-4

Vitamin D

Gene Expression

Abstract

BACKGROUND: Ulcerative Colitis (UC) is a chronic inflammatory disorder of the large intestine. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a member of the immunoglobulin superfamily, which binds B7-1 and B7-2 on APCs (antigen-presenting cells), and induces APCs to produce an inhibitory signal to T cells. The aim of this study was to investigate the effect of Vitamin D on CTLA-4 Gene Expression in whole blood samples of patients with UC. METHODS: 90 patients with mild to moderate UC were randomized to receive either a single injection of 7. 5 mg Vitamin D3 or 1 mL normal saline. 90 days following the intervention fold changes in CTLA-4 mRNA expression were determined and statistical comparisons between the two groups were performed. RESULTS: Serum Vitamin D increased significantly only in the Vitamin D group. CTLA-4 fold changes were significantly higher in the Vitamin D group compared with the placebo group (median ± IQR: 1. 21 ± 2. 3 vs. 1. 00 ± 1. 5, respectively; p = 0. 007). CONCLUSION: The results of this study revealed that Vitamin D administration in patients with UC enhances the CTLA-4 Gene Expression.

Cites

No record.

References

No record.

Cite

APA: Copy

SHARIFI, AMROLLAH, VAHEDI, HOMAYOON, HONARVAR, MOHAMMAD REZA, ALIPOOR, BEHNAM, NIKNIAZ, ZEINAB, RAFIEI, HOSSEIN, & HOSSEINZADEH ATTAR, MOHAMMAD JAVAD. (2019). Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 11(4), 199-204. SID. https://sid.ir/paper/977756/en

Vancouver: Copy

SHARIFI AMROLLAH, VAHEDI HOMAYOON, HONARVAR MOHAMMAD REZA, ALIPOOR BEHNAM, NIKNIAZ ZEINAB, RAFIEI HOSSEIN, HOSSEINZADEH ATTAR MOHAMMAD JAVAD. Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2019;11(4):199-204. Available from: https://sid.ir/paper/977756/en

IEEE: Copy

AMROLLAH SHARIFI, HOMAYOON VAHEDI, MOHAMMAD REZA HONARVAR, BEHNAM ALIPOOR, ZEINAB NIKNIAZ, HOSSEIN RAFIEI, and MOHAMMAD JAVAD HOSSEINZADEH ATTAR, “Vitamin D Increases CTLA-4 Gene Expression in Patients with Mild to Moderate Ulcerative Colitis,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 11, no. 4, pp. 199–204, 2019, [Online]. Available: https://sid.ir/paper/977756/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops