مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

92
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

172
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Anti-inflammatory and Antioxidant Properties of PLGA Nanoparticles Produced From Kombucha Extract on A2780 Human Ovarian Cancer Cell Line

Pages

  65-71

Keywords

Poly (Lactic-co-glycolic acid) nanoparticles 

Abstract

 Background: Anti-cancer agents encapsulated in nanoparticles (NPs) can result in higher efficiency. Kombucha is a fermented tea beverage, and previous reports support its anti-cancer properties. Objectives: The present study aimed to evaluate the anti-cancer and anti-inflammatory properties of poly (lactic-co-glycolic acid) loaded Kombucha NPs (PLGA-K-NPs) against the A2780 human Ovarian cancer cell line. Methods: The antioxidant activity was analyzed using ferric reducing ability of plasma and 2, 2’-azinobis( 3-ethylbenzothiazoline-6-sulfonic acid) assays, along with the measurement of catalase (CAT) gene expression. The gene expression of three interleukins (IL-1β , IL-6, and IL-10) was also determined to demonstrate the anti-inflammatory properties of NPs. Results: The results revealed the Antioxidant effects of PLGA-K-NPs on the studied cell lines by increasing Fe3+ reduction, inhibiting the free radical formation (P < 0. 001), and increasing the expression of the CAT gene (P < 0. 001). In addition, NPs could significantly elevate the gene expression of IL-10 (P < 0. 01) as an anti-inflammatory cytokine at a 40 μ g/mL concentration, while reducing the expression of IL-1β and IL-6, and inflammatory cytokines at all tested concentrations (P < 0. 01). Conclusion: According to the obtained results, PLGA-K-NPs have anti-inflammatory and anti-oxidant properties, therefore, they can be considered as a compound in the treatment of Ovarian cancer. However, it needs to be further investigated in animal studies to clarify more details.

Multimedia

  • No record.

    • Cites

  • No record.

    • References

    Cite

    APA: Copy

    GHANDEHARI, SARA, HOMAYOUNI TABRIZI, MASOUD, Izadi Nia, Jafar, & GOODARZI, MOHAMMAD TAGHI. (2021). Anti-inflammatory and Antioxidant Properties of PLGA Nanoparticles Produced From Kombucha Extract on A2780 Human Ovarian Cancer Cell Line. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, 9(2), 65-71. SID. https://sid.ir/paper/978709/en

    Vancouver: Copy

    GHANDEHARI SARA, HOMAYOUNI TABRIZI MASOUD, Izadi Nia Jafar, GOODARZI MOHAMMAD TAGHI. Anti-inflammatory and Antioxidant Properties of PLGA Nanoparticles Produced From Kombucha Extract on A2780 Human Ovarian Cancer Cell Line. AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY[Internet]. 2021;9(2):65-71. Available from: https://sid.ir/paper/978709/en

    IEEE: Copy

    SARA GHANDEHARI, MASOUD HOMAYOUNI TABRIZI, Jafar Izadi Nia, and MOHAMMAD TAGHI GOODARZI, “Anti-inflammatory and Antioxidant Properties of PLGA Nanoparticles Produced From Kombucha Extract on A2780 Human Ovarian Cancer Cell Line,” AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY, vol. 9, no. 2, pp. 65–71, 2021, [Online]. Available: https://sid.ir/paper/978709/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button