A Pusher and a Clip Applied to Hind Paws Under Isoﬂ urane Sedation to Evaluate Neuropathic Pain in a CCI Model

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Nobuhara Reiko; ITO AKIHIRO; Nakagawa Masafumi; IKEMOTO TATSUNORI; Narita Kimimasa; NISHIHARA MAKOTO; Kinoshita Yukio; Arai Young Chang

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Journal Paper

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Journal: Anesthesiology and Pain Medicine Year:2021 | Volume:11 | Issue:6 Page(s): 0-0

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Title

A Pusher and a Clip Applied to Hind Paws Under Isoﬂ urane Sedation to Evaluate Neuropathic Pain in a CCI Model

Author(s)

Keywords

Evaluation of Chronic Pain

CCI Animals

Clips and Pushers

Isoﬂurane Sedation

Abstract

Rodent behavior assessments have been developed to evaluate pain. However, their ﬁ dgety activity and reactivity to human contact make it hard to activate animals in a consistent manner and get uniform and trustworthy responses. The present study was performed on prairie voles (aged 8 weeks). Sham (7 male prairie voles) and chronic constriction injury (CCI) (8 male prairie voles) rodents were investigated before surgery and four and seven days later. Each animal was assessed for nociceptive behavior. Pressure and mechanical threshold tests were conducted by the application of three diﬀ erent pushers to the center of hind paws and arterial clips to the toes while sedated with isoﬂ urane. The CCI aﬀ ected right lower extremity prominently increased nociceptive behavior scores four and seven days after the experiment, and the CCI aﬀ ected right hind paw prominently decreased pressure and mechanical threshold tests four and seven days after the experiment. The pressure and mechanical thresholds were relevant to the scorings of nociceptive behavior in CCI model animals.

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APA: Copy

Nobuhara, Reiko, ITO, AKIHIRO, Nakagawa, Masafumi, IKEMOTO, TATSUNORI, Narita, Kimimasa, NISHIHARA, MAKOTO, Kinoshita, Yukio, & Arai, Young Chang. (2021). A Pusher and a Clip Applied to Hind Paws Under Isoﬂ urane Sedation to Evaluate Neuropathic Pain in a CCI Model. ANESTHESIOLOGY AND PAIN MEDICINE, 11(6), 0-0. SID. https://sid.ir/paper/979250/en

Vancouver: Copy

Nobuhara Reiko, ITO AKIHIRO, Nakagawa Masafumi, IKEMOTO TATSUNORI, Narita Kimimasa, NISHIHARA MAKOTO, Kinoshita Yukio, Arai Young Chang. A Pusher and a Clip Applied to Hind Paws Under Isoﬂ urane Sedation to Evaluate Neuropathic Pain in a CCI Model. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2021;11(6):0-0. Available from: https://sid.ir/paper/979250/en

IEEE: Copy

Reiko Nobuhara, AKIHIRO ITO, Masafumi Nakagawa, TATSUNORI IKEMOTO, Kimimasa Narita, MAKOTO NISHIHARA, Yukio Kinoshita, and Young Chang Arai, “A Pusher and a Clip Applied to Hind Paws Under Isoﬂ urane Sedation to Evaluate Neuropathic Pain in a CCI Model,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 11, no. 6, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/979250/en

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