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Title

Genetic and biochemical studies of hepatic carcinoma in the Egyptian population

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Abstract

 Background: Hepatocellular carcinoma (HCC), a deadly malignancy of the liver, is considered the third leading reason behind cancer deaths. It is more frequent in men than in women of ages above 50. Liver disease, leading to liver cirrhosis (LC), is mostly caused by alcoholism abuse, reaction diseases of the liver, or viral hepatitis B or C infection. Interleukin‑ 6 (IL‑ 6) is considered an effective pro‑ inflammatory cytokine, which plays a crucial role in the host defense mechanism. Its level is higher in HCC patients than in LC cases, indicating that tumor cells increase the production of cytokines. The X‑ ray repair cross‑ complementing group 1 (XRCC1) gene is a major DNA repair gene. It acts as a scaffold of various activities that are concerned in the repairing method by interacting with components of base excision repair. This study aims to measure the serum concentrations of IL6 and C‑ reactive protein (CRP) and investigate whether XRCC1 Arg194Trp and Arg399Gln polymorphisms are related to HCC disease. Materials and Methods: Whole‑ blood DNA was extracted from 123 HCC patients and 123 healthy volunteers. Tetra‑ primer amplification refractory mutation system was performed in the detection of XRCC1 Arg399Gln and Arg194Trp polymorphisms. Results: Serum concentration levels of IL‑ 6 and CRP are significantly higher in patients with HCC than in control subjects. The allelic and genotype frequency distributions of XRCC1 (Arg399Gln and Arg194Trp) are significantly increased in HCC cases compared to healthy volunteers. Conclusion: Arg/Gln, Arg/Trp, Gln/Gln, and Trp/Trp genotypes are associated with higher risk HCC than the Arg/Arg genotype.

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    APA: Copy

    Elkhoudary, Amany F., Elmougy, Rehab, Elsaid, Afaf, Wahba, Yahya, & Abdel Aziz, Abdel Aziz F.. (2021). Genetic and biochemical studies of hepatic carcinoma in the Egyptian population. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 26(-), 0-0. SID. https://sid.ir/paper/979259/en

    Vancouver: Copy

    Elkhoudary Amany F., Elmougy Rehab, Elsaid Afaf, Wahba Yahya, Abdel Aziz Abdel Aziz F.. Genetic and biochemical studies of hepatic carcinoma in the Egyptian population. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2021;26(-):0-0. Available from: https://sid.ir/paper/979259/en

    IEEE: Copy

    Amany F. Elkhoudary, Rehab Elmougy, Afaf Elsaid, Yahya Wahba, and Abdel Aziz F. Abdel Aziz, “Genetic and biochemical studies of hepatic carcinoma in the Egyptian population,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 26, no. -, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/979259/en

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