Adding Dexmedetomidine to Bupivacaine in Ultrasound-guided Thoracic Paravertebral Block for Pain Management after Upper Abdominal Surgery: A Double-blind Randomized Controlled Trial

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ALIMIAN MAHZAD; IMANI FARNAD; RAHIMZADEH POUPAK; FAIZ SEYED HAMID REZA; Bahari Sejahrood Leila; Hertling Arthur C.

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Journal: Anesthesiology and Pain Medicine Year:2021 | Volume:11 | Issue:6 Page(s): 0-0

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Title

Adding Dexmedetomidine to Bupivacaine in Ultrasound-guided Thoracic Paravertebral Block for Pain Management after Upper Abdominal Surgery: A Double-blind Randomized Controlled Trial

Author(s)

Keywords

Dexmedetomidine

Upper Abdominal Surgery

Ultrasound Guided

Thoracic Paravertebral Block

Postoperative Pain

Abstract

Background: Paravertebral blocks are one of the possible Postoperative Pain management modalities after laparotomy. Adjuvants to local anesthetics, including alpha agonists, have been shown to lead to better pain relief and increased duration of analgesia. Objectives: The aim of this study is to examine the eﬀ ect of adding Dexmedetomidine to bupivacaine for ultrasound-guided paravertebral blocks in laparotomy. Methods: In this double-blind, randomized controlled trial (RCT), we enrolled 42 patients scheduled for T6 to T8 Thoracic Paravertebral Block (TPVB) for analgesia after laparotomy. The patients were randomly assigned into two groups of BD (bupivacaine 2. 5 mg/mL 20 mL plus Dexmedetomidine 100 g) and B (bupivacaine 20 mL alone). Following surgery, intravenous fentanyl patientcontrolled analgesia was initiated. The numerical rating scale (NRS) for pain, sedation score, total analgesic consumption, time to ﬁ rst analgesic requirement, side eﬀ ects (such as nausea and vomiting), respiratory depression, and patients’ satisfaction during the ﬁ rst 48 hours of evaluation were compared in the two groups. Results: Pain scores and mean total analgesic consumption at the ﬁ rst 48 hours in the BD group were signiﬁ cantly lower than Group B (P = 0. 03 and P < 0. 001, respectively). The time of ﬁ rst analgesic request was signiﬁ cantly longer in BD group (P < 0. 001). Sedation scores and side eﬀ ects did not diﬀ er signiﬁ cantly between the two groups. Conclusions: Adding Dexmedetomidine to bupivacaine for TPVB after laparotomy yielded better Postoperative Pain management without signiﬁ cant complications.

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APA: Copy

ALIMIAN, MAHZAD, IMANI, FARNAD, RAHIMZADEH, POUPAK, FAIZ, SEYED HAMID REZA, Bahari Sejahrood, Leila, & Hertling, Arthur C.. (2021). Adding Dexmedetomidine to Bupivacaine in Ultrasound-guided Thoracic Paravertebral Block for Pain Management after Upper Abdominal Surgery: A Double-blind Randomized Controlled Trial. ANESTHESIOLOGY AND PAIN MEDICINE, 11(6), 0-0. SID. https://sid.ir/paper/983620/en

Vancouver: Copy

ALIMIAN MAHZAD, IMANI FARNAD, RAHIMZADEH POUPAK, FAIZ SEYED HAMID REZA, Bahari Sejahrood Leila, Hertling Arthur C.. Adding Dexmedetomidine to Bupivacaine in Ultrasound-guided Thoracic Paravertebral Block for Pain Management after Upper Abdominal Surgery: A Double-blind Randomized Controlled Trial. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2021;11(6):0-0. Available from: https://sid.ir/paper/983620/en

IEEE: Copy

MAHZAD ALIMIAN, FARNAD IMANI, POUPAK RAHIMZADEH, SEYED HAMID REZA FAIZ, Leila Bahari Sejahrood, and Arthur C. Hertling, “Adding Dexmedetomidine to Bupivacaine in Ultrasound-guided Thoracic Paravertebral Block for Pain Management after Upper Abdominal Surgery: A Double-blind Randomized Controlled Trial,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 11, no. 6, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/983620/en

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