Association of Interleukin-16 Gene Polymorphisms rs11556218 T/G and rs4072111 C/T with Risk of Breast Cancer in an Iranian Population

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HAMTA AHMAD; Hosseinpour Maliheh; KOMIJANI MAJID

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Journal Paper

Paper Information

Journal: MEDICAL LABORATORY JOURNAL Year:2021 | Volume:15 | Issue:4 Page(s): 15-20

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Title

Association of Interleukin-16 Gene Polymorphisms rs11556218 T/G and rs4072111 C/T with Risk of Breast Cancer in an Iranian Population

Author(s)

HAMTA AHMAD | Hosseinpour Maliheh | KOMIJANI MAJID | Issue Writer Certificate

Keywords

Breast Neoplasms

Interleukin-16

Polymorphism

Single Nucleotide

Abstract

Background and objectives: Breast cancer is the leading cause of death in women. Cytokines regulate the intensity and continuity of immune response by balancing cell-mediated immunity and humoral responses. This study aimed to investigate the relationship between two Polymorphisms of the Interleukin-16 (IL-16) gene and risk of breast cancer. Methods: Blood samples were collected from 80 breast cancer patients and 80 healthy individuals. Polymorphisms rs11556218 T/G and rs4072111 C/T were investigated by polymerase chain reaction-restriction fragment length Polymorphism (RFLP-PCR). Then, genotype and allele frequency distributions were evaluated in each group using the SPSS software (version 24). Results: The frequency of genotype rs11556218 differed significantly between the patients and controls (P=0. 007). The TG genotype (odds ratio [OR]= 2. 471, 95% confidence intervals [CI]: 1. 229-4. 965, P= 0. 001) and total TG+GG genotypes (OR= 3. 095, 95% CI: 1. 624-5. 899, P= 0. 001) had a significant relationship with increased risk for breast cancer. The allele and genotype frequencies of rs4072111 C/T Polymorphism did not differ significantly between the patients and controls. Conclusion: Our findings suggest that the rs11556218 T/G Polymorphism of the IL-16 gene may be associated with susceptibility to breast cancer.

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APA: Copy

HAMTA, AHMAD, Hosseinpour, Maliheh, & KOMIJANI, MAJID. (2021). Association of Interleukin-16 Gene Polymorphisms rs11556218 T/G and rs4072111 C/T with Risk of Breast Cancer in an Iranian Population. MEDICAL LABORATORY JOURNAL, 15(4), 15-20. SID. https://sid.ir/paper/983930/en

Vancouver: Copy

HAMTA AHMAD, Hosseinpour Maliheh, KOMIJANI MAJID. Association of Interleukin-16 Gene Polymorphisms rs11556218 T/G and rs4072111 C/T with Risk of Breast Cancer in an Iranian Population. MEDICAL LABORATORY JOURNAL[Internet]. 2021;15(4):15-20. Available from: https://sid.ir/paper/983930/en

IEEE: Copy

AHMAD HAMTA, Maliheh Hosseinpour, and MAJID KOMIJANI, “Association of Interleukin-16 Gene Polymorphisms rs11556218 T/G and rs4072111 C/T with Risk of Breast Cancer in an Iranian Population,” MEDICAL LABORATORY JOURNAL, vol. 15, no. 4, pp. 15–20, 2021, [Online]. Available: https://sid.ir/paper/983930/en

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