Voluntary exercise could reduce sperm malformations by improving hypothalamus-hypophysis-gonadal axis and kisspeptin/leptin signaling in type 2 diabetic rats

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Kharazi Uldouz; KEYHANMANESH RANA; Hamidian Gholam Reza; GHADERPOUR SABER; Ghiasi Rafighe

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Journal Paper

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Journal: Iranian Journal of Basic Medical Sciences Year:2021 | Volume:24 | Issue:12 Page(s): 1624-1631

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Title

Voluntary exercise could reduce sperm malformations by improving hypothalamus-hypophysis-gonadal axis and kisspeptin/leptin signaling in type 2 diabetic rats

Author(s)

Keywords

Diabetes

Hypophysis

Hypothalamus

Kisspeptin

Leptin

Sperm malformations

Voluntary exercise

Abstract

Objective(s): Most male patients with type 2 Diabetes mellitus (T2DM) experience infertility. It is well established that regular physical activity could alleviate diabetic infertility symptoms. This study was designed to determine the effect of Voluntary exercise on sperm malformation. Materials and Methods: Thirty-two male Wistar rats were randomly divided into control (C), diabetic (D), Voluntary exercise (Ex), and diabetic-Voluntary exercise (D-Ex) groups. Diabetes was induced by an intraperitoneal injection of streptozotocin (35 mg/kg) followed by a high-fat diet for four weeks. Voluntary exercise was performed by placing the animals in the rotary wheel cages for ten weeks. Sperm malformations were analyzed. Moreover, the hypothalamic Leptin, Kisspeptin, Kisspeptin receptors (KissR), as well as plasma LH, FSH, testosterone, and Leptin levels were evaluated. Results: Results showed that induction of T2DM caused increased sperm malformation, plasma, and hypothalamic Leptin as well as decreased hypothalamic Kisspeptin, KissR, and plasma LH levels compared with the C group (P<0. 001 to P<0. 01). Voluntary exercise in the Ex group increased hypothalamic KissR, plasma FSH, LH, and testosterone levels compared with the C group; however, it decreased sperm malformation and hypothalamic Leptin levels (P<0. 001 to P<0. 05). Voluntary exercise in the D-Ex group reduced sperm malformation, hypothalamic Leptin, and plasma testosterone while elevated hypothalamic Kisspeptin and KissR protein levels compared with the D group (P<0. 001 to P<0. 01). Conclusion: The results illustrated Voluntary exercise reduces Sperm malformations by improving the HHG axis and Kisspeptin/Leptin signaling in rats with T2DM.

Cites

Pathological and structural study of cardiac striated muscle and quadriceps along with the study of microscopic changes in liver, kidney and lung tissue following short-term and long-term resistance exercises in male rats

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APA: Copy

Kharazi, Uldouz, KEYHANMANESH, RANA, Hamidian, Gholam Reza, GHADERPOUR, SABER, & Ghiasi, Rafighe. (2021). Voluntary exercise could reduce sperm malformations by improving hypothalamus-hypophysis-gonadal axis and kisspeptin/leptin signaling in type 2 diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 24(12), 1624-1631. SID. https://sid.ir/paper/984645/en

Vancouver: Copy

Kharazi Uldouz, KEYHANMANESH RANA, Hamidian Gholam Reza, GHADERPOUR SABER, Ghiasi Rafighe. Voluntary exercise could reduce sperm malformations by improving hypothalamus-hypophysis-gonadal axis and kisspeptin/leptin signaling in type 2 diabetic rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2021;24(12):1624-1631. Available from: https://sid.ir/paper/984645/en

IEEE: Copy

Uldouz Kharazi, RANA KEYHANMANESH, Gholam Reza Hamidian, SABER GHADERPOUR, and Rafighe Ghiasi, “Voluntary exercise could reduce sperm malformations by improving hypothalamus-hypophysis-gonadal axis and kisspeptin/leptin signaling in type 2 diabetic rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 24, no. 12, pp. 1624–1631, 2021, [Online]. Available: https://sid.ir/paper/984645/en

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