THE ROLE AND EFFECT OF FINASTERIDE ON THE SPERMATOGENESIS, PROSTATE GLAND AND EPIDIDYM OF MATURE NMRI MOUSE IN IN VIVO AND IN VITRO CONDITIONS

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PARIVAR KAZEM; YAGHMAEI PARICHEHR; SEKHAVATI SAHAR

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2010 | Volume:20 | Issue:3 Page(s): 148-156

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Title

THE ROLE AND EFFECT OF FINASTERIDE ON THE SPERMATOGENESIS, PROSTATE GLAND AND EPIDIDYM OF MATURE NMRI MOUSE IN IN VIVO AND IN VITRO CONDITIONS

Author(s)

PARIVAR KAZEM | YAGHMAEI PARICHEHR | SEKHAVATI SAHAR | Issue Writer Certificate

Keywords

FINASTERIDEQ3

DIHYDROTESTOSTERONEQ3

PROSTATEQ2

SPERMATOGENESISQ3

EPIDIDYMISQ2

NMRI MOUSEQ2

Abstract

Background: FINASTERIDE, a 4-azasteroid compound, is a specific inhibitor of type P 5α-reductase that converts testosterone into 5α-dihydrotestosterone. In the present study, the effects of human dose of FINASTERIDE on the number of spermatogenic cells, seminiferous, prostatic and epididymal tubules diameter and thickness of mature NMRI MOUSE were investigated, both in in vivo and in vitro conditions.Material and methods: In this experimental study, in in vivo condition, 18 mature NMRI mice were divided into 3 groups of 6: control (without treatment), sham (treatment whit physiologic serum) and experimental (treatment with drug). Experimental group was received intraperitoneal injection of 5 mg/kg/day FINASTERIDE for 7 days. In in vitro condition, testes, PROSTATEs and epididyms of 18 mature NMRI mice were divided into 3 groups of 6: control (fixation with bouin without treatment), sham (treatment with physiologic serum) and experimental (treatment with 5 mg/kg/day of FINASTERIDE in culture media for 3 days). Data were analyzed using one way ANOVA and Tukey test by SPSS software. P- value< 0.05 was considered significant.Results: In in vivo condition, treatment with FINASTERIDE did not cause significant reduction in the number of spermatogenic cells, seminiferous tubules diameter compared with control group. But, in in vitro condition, significant decrease was observed. In both conditions, the drug could cause significant decrease in prostatic tubules diameter and thickness compared with control group. Diameter and thickness of EPIDIDYMIS tubules were decreased just in in vitro condition.Conclusion: FINASTERIDE can act in long-term treatment, high doses and in in vitro condition better than other conditions.

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APA: Copy

PARIVAR, KAZEM, YAGHMAEI, PARICHEHR, & SEKHAVATI, SAHAR. (2010). THE ROLE AND EFFECT OF FINASTERIDE ON THE SPERMATOGENESIS, PROSTATE GLAND AND EPIDIDYM OF MATURE NMRI MOUSE IN IN VIVO AND IN VITRO CONDITIONS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 20(3), 148-156. SID. https://sid.ir/paper/98467/en

Vancouver: Copy

PARIVAR KAZEM, YAGHMAEI PARICHEHR, SEKHAVATI SAHAR. THE ROLE AND EFFECT OF FINASTERIDE ON THE SPERMATOGENESIS, PROSTATE GLAND AND EPIDIDYM OF MATURE NMRI MOUSE IN IN VIVO AND IN VITRO CONDITIONS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2010;20(3):148-156. Available from: https://sid.ir/paper/98467/en

IEEE: Copy

KAZEM PARIVAR, PARICHEHR YAGHMAEI, and SAHAR SEKHAVATI, “THE ROLE AND EFFECT OF FINASTERIDE ON THE SPERMATOGENESIS, PROSTATE GLAND AND EPIDIDYM OF MATURE NMRI MOUSE IN IN VIVO AND IN VITRO CONDITIONS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 20, no. 3, pp. 148–156, 2010, [Online]. Available: https://sid.ir/paper/98467/en

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