GENETIC DIVERSITY OF THE DIHYDROPTEROATE SYNTHASE GENE IN PLASMODIUM VIVAX IN HORMOZGAN PROVINCE

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HAGHIGHI ALI; MAGHSOUDLOURAD FATEMEH SOGHRA; SHARIFI SARASIABI KHOJASTEH; SEYYED TABAII SEYYED JAVAD; TAGHIPOUR NILOOFAR; NAZEMALHOSSEINI MOJARAD EHSAN; HOSSEINZADEH NAHID; GACHKAR LATIF

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2014 | Volume:23 | Issue:1 (SUPP.) Page(s): 6-10

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Title

GENETIC DIVERSITY OF THE DIHYDROPTEROATE SYNTHASE GENE IN PLASMODIUM VIVAX IN HORMOZGAN PROVINCE

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Keywords

GENETIC DIVERSITYQ2

DIHIDROPTEROATE SYNTHETASE GENEQ2

PLASMODIUM VIVAXQ3

PCRQ2

HORMOZGAN PROVINCEQ2

Abstract

Background: Malaria is the most important parasitic disease in the world and in malaria-prone regions is considered as the most serious threat to the human health. The aim of this study was polymorphisms analysis of the dihidropteroate synthetase (dhps) gene in p. vivax in HORMOZGAN PROVINCE and to determine the prevalence of mutations in codons 382, 383, 512, 553 and 585 related to sulphadoxine resistance in PLASMODIUM VIVAX.Materials and Methods: 118 isolates of P. vivax which had been prepared between 2007 and 2008 to study about dihydrofolate reductase-thymidylate synthase (pvdhfr) gene were also used in this study to analyze GENETIC DIVERSITY of the dihidropteroate synthetase (pvdhp) gene of P. vivax.Results: Of the 118 blood samples infected with P. vivax, 46 and 72 samples were obtained from Minab and Jask, respectively. No mutant alleles were found in 5 target codons using Nested-PCR and sequencing methods. However one novel mutation in codon 421 in three isolates (2.54%) was revealed.Conclusion: According to the observed mutation in the gene pvdhfr (data not published), and likely resistance to pyrimethamine, and lack of mutations observed in the pvdhps target codons in this study on the same samples, no resistance to the sulphadoxine "and thus to the Fansidar in P. vivax in HORMOZGAN PROVINCE can be concluded.

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APA: Copy

HAGHIGHI, ALI, MAGHSOUDLOURAD, FATEMEH SOGHRA, SHARIFI SARASIABI, KHOJASTEH, SEYYED TABAII, SEYYED JAVAD, TAGHIPOUR, NILOOFAR, NAZEMALHOSSEINI MOJARAD, EHSAN, HOSSEINZADEH, NAHID, & GACHKAR, LATIF. (2014). GENETIC DIVERSITY OF THE DIHYDROPTEROATE SYNTHASE GENE IN PLASMODIUM VIVAX IN HORMOZGAN PROVINCE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(1 (SUPP.)), 6-10. SID. https://sid.ir/paper/98490/en

Vancouver: Copy

HAGHIGHI ALI, MAGHSOUDLOURAD FATEMEH SOGHRA, SHARIFI SARASIABI KHOJASTEH, SEYYED TABAII SEYYED JAVAD, TAGHIPOUR NILOOFAR, NAZEMALHOSSEINI MOJARAD EHSAN, HOSSEINZADEH NAHID, GACHKAR LATIF. GENETIC DIVERSITY OF THE DIHYDROPTEROATE SYNTHASE GENE IN PLASMODIUM VIVAX IN HORMOZGAN PROVINCE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2014;23(1 (SUPP.)):6-10. Available from: https://sid.ir/paper/98490/en

IEEE: Copy

ALI HAGHIGHI, FATEMEH SOGHRA MAGHSOUDLOURAD, KHOJASTEH SHARIFI SARASIABI, SEYYED JAVAD SEYYED TABAII, NILOOFAR TAGHIPOUR, EHSAN NAZEMALHOSSEINI MOJARAD, NAHID HOSSEINZADEH, and LATIF GACHKAR, “GENETIC DIVERSITY OF THE DIHYDROPTEROATE SYNTHASE GENE IN PLASMODIUM VIVAX IN HORMOZGAN PROVINCE,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 1 (SUPP.), pp. 6–10, 2014, [Online]. Available: https://sid.ir/paper/98490/en

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