THE STUDY OF THE ASSOCIATION BETWEEN VITAMIN D RECEPTOR COMMON GENETIC POLYMORPHISMS AND SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS

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TAJIK NADER; JAFARI MOHAMMAD; NASIRI MOHAMMAD REZA; MOUSAVI T.; FARNIA P.; SALEK MOGHADAM ALI REZA

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Journal: Razi Journal of Medical Sciences Year:2009 | Volume:16 | Issue:64 Page(s): 14-21

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Title

THE STUDY OF THE ASSOCIATION BETWEEN VITAMIN D RECEPTOR COMMON GENETIC POLYMORPHISMS AND SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS

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Keywords

PULMONARY TUBERCULOSISQ3

VITAMIN DQ2

VITAMIN D RECEPTORQ3

GENETIC POLYMORPHISMQ2

Abstract

Background and Aim: In addition to exposure to Mycobacterium tuberculosis (MTB), development of tuberculosis is influenced by environmental and host genetic factors, and clinical disease only occurs in less than 10% of the infected individuals. VITAMIN D metabolism leads to activation of macrophages and restricts the intracellular growth of mycobacterium. This effect may be influenced by polymorphisms in the VITAMIN D receptor (VDR) gene. In the present study we investigated the impact of VDR gene variation in susceptibility to PULMONARY TUBERCULOSIS.Materials and Methods: This study was a case-control analysis in an Iranian population. We evaluated four VDR gene polymorphisms [defined by the presence of restriction endonuclease sitesfor FokI (F/f), BsmI (B/b), TaqI (T/t), and ApaI (A/a)] in 96 patients with tuberculosis and 122 matched healthy controls. A modified polymerase chain reaction with sequence-specific primers (PCR-SSP) technique was used to identify these polymorphisms in VDR gene simultaneously. Chi square was used for data analysis.Results: Comparison of allele and genotype frequencies for the above VDR gene polymorphic sites revealed no significant difference between patient and control groups.Conclusion: This data may rule out the importance of VDR gene polymorphisms in susceptibility to tuberculosis among Iranian population.

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APA: Copy

TAJIK, NADER, JAFARI, MOHAMMAD, NASIRI, MOHAMMAD REZA, SALEK MOGHADAM, ALI REZA, MOUSAVI, T., & FARNIA, P.. (2009). THE STUDY OF THE ASSOCIATION BETWEEN VITAMIN D RECEPTOR COMMON GENETIC POLYMORPHISMS AND SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 16(64), 14-21. SID. https://sid.ir/paper/9865/en

Vancouver: Copy

TAJIK NADER, JAFARI MOHAMMAD, NASIRI MOHAMMAD REZA, SALEK MOGHADAM ALI REZA, MOUSAVI T., FARNIA P.. THE STUDY OF THE ASSOCIATION BETWEEN VITAMIN D RECEPTOR COMMON GENETIC POLYMORPHISMS AND SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2009;16(64):14-21. Available from: https://sid.ir/paper/9865/en

IEEE: Copy

NADER TAJIK, MOHAMMAD JAFARI, MOHAMMAD REZA NASIRI, ALI REZA SALEK MOGHADAM, T. MOUSAVI, and P. FARNIA, “THE STUDY OF THE ASSOCIATION BETWEEN VITAMIN D RECEPTOR COMMON GENETIC POLYMORPHISMS AND SUSCEPTIBILITY TO PULMONARY TUBERCULOSIS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 16, no. 64, pp. 14–21, 2009, [Online]. Available: https://sid.ir/paper/9865/en

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