Modulation of Fibroblast Growth Factor-21 and , klotho Proteins Expression in Type 2 DiabeticWomen with Non-alcoholic Fatty Liver Disease Following Endurance and Strength Training

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astinchap afsaneh; Monazzami Amirabbas; Fereidoonfara Khadijeh; RAHIMI ZOHREH; RAHIMI MEHRALI

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Journal: Hepatitis Monthly Year:2021 | Volume:21 | Issue:7 Page(s): 0-0

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Title

Modulation of Fibroblast Growth Factor-21 and , klotho Proteins Expression in Type 2 DiabeticWomen with Non-alcoholic Fatty Liver Disease Following Endurance and Strength Training

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Abstract

Background: There is limited research on the effects of physical activity with moderate intensity on , klotho (BKL) and fibroblast growth factor-21 (FGF-21) proteins expression in diabetic patients with non-alcoholic fatty liver disease (NAFLD). Objectives: This study was aimed to determine the effects of eight weeks of endurance and resistance training on BKL and FGF-21 proteins expression in diabetic women with NAFLD. Methods: Forty-five diabetic women (age: 51, 8 years, height: 158, 2 cm, weight: 75, 8 kg) with NAFLD participated. The subjects were randomly divided into three groups, including control (n = 15), endurance training (n = 15), and resistance training (n = 15). The enzyme-linked immunosorbent assay (ELISA) was used to measure BKL and FGF-21 proteins. Two-wayANOVA with repeated measures was applied to determine differences at a significant level of P < 0. 05. Results: Eight weeks of endurance and resistance training reduced AST, ALT, and FGF-21 (25, 26, 19% and 13, 16, 13%, respectively) and increased BKL (16% and 18, respectively). However, in the variables of HDL, insulin, AST, ALT, FGF-21, and BKL, a significant difference was observed in the control group (P < 0. 05). Also, there was a significant difference between the control and training groups in BKL and FGF21 proteins expression (P < 0. 05), but no significant difference was observed between the two training groups (P > 0. 05). Conclusions: The results suggest that both moderate-intensity endurance and resistance training can modulate the destructive effects of type 2 diabetes and NAFLD on BKL and FGF-21 proteins expression, and there is no difference between the two training methods.

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APA: Copy

astinchap, afsaneh, Monazzami, Amirabbas, Fereidoonfara, Khadijeh, RAHIMI, ZOHREH, & RAHIMI, MEHRALI. (2021). Modulation of Fibroblast Growth Factor-21 and , klotho Proteins Expression in Type 2 DiabeticWomen with Non-alcoholic Fatty Liver Disease Following Endurance and Strength Training. HEPATITIS MONTHLY, 21(7), 0-0. SID. https://sid.ir/paper/987916/en

Vancouver: Copy

astinchap afsaneh, Monazzami Amirabbas, Fereidoonfara Khadijeh, RAHIMI ZOHREH, RAHIMI MEHRALI. Modulation of Fibroblast Growth Factor-21 and , klotho Proteins Expression in Type 2 DiabeticWomen with Non-alcoholic Fatty Liver Disease Following Endurance and Strength Training. HEPATITIS MONTHLY[Internet]. 2021;21(7):0-0. Available from: https://sid.ir/paper/987916/en

IEEE: Copy

afsaneh astinchap, Amirabbas Monazzami, Khadijeh Fereidoonfara, ZOHREH RAHIMI, and MEHRALI RAHIMI, “Modulation of Fibroblast Growth Factor-21 and , klotho Proteins Expression in Type 2 DiabeticWomen with Non-alcoholic Fatty Liver Disease Following Endurance and Strength Training,” HEPATITIS MONTHLY, vol. 21, no. 7, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/987916/en

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