Preimplantation Genetic Testing for Couples with Balanced Chromosomal Rearrangements

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Shetty Sachin; Nair Jiny; Johnson Jnapti; Shetty Navya; Kumar J Ajay; Thondehalmath Nirmala; Ganesh Deepanjali; R Bhat Vidyalakshmi; M. Sajana; Anjana R.; Nayak Rajsekhar; Gunasheela Devika; S Kadandale Jayarama; Shetty Swathi

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Journal Paper

Paper Information

Journal: Journal of Reproduction & Infertility Year:2022 | Volume:23 | Issue:3 Page(s): 213-223

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Title

Preimplantation Genetic Testing for Couples with Balanced Chromosomal Rearrangements

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Keywords

Aneuploidy

Balanced chromosomal rearrangements

In vitro fertilization

Inversion

Preimplantation genetic testing

Reciprocal translocation

Recurrent miscarriages

Robertsonian translocation

Abstract

Background: Chromosomal rearrangements play an important role in infertility. Carriers of chromosomal rearrangements have a lower chance of producing normal or balanced gametes due to abnormal segregation of chromosomes at meiosis, which leads to recurrent spontaneous abortions and infertility. Preimplantation genetic testing for structural chromosome rearrangements (PGT-SR) is offered to couples who have Balanced chromosomal rearrangements in order to select embryos with a balanced karyotype prior to implantation, thereby increasing the chances of pregnancy. The purpose of the current study was to assess the outcomes of PGT-SR in patients carrying various Balanced chromosomal rearrangements and to assess their clinical pregnancy outcome after In vitro fertilization (IVF). Methods: In this study, infertile couples with balanced chromosomal abnormalities undergoing PGT-SR were retrospectively analyzed at a single fertility center from January 2016 to December 2019. Results: PGT-SR was performed on 87 embryos from 22 couples in whom one partner carried a balanced translocation or an Inversion. Fifty-seven (65. 5%) of these embryos had unbalanced or sporadic aneuploidies, 30 (34. 5%) embryos were normal or chromosomally balanced, which were then transferred in 18 couples. A higher rate of unbalanced translocations in comparison to sporadic aneuploidies was observed in couples with Reciprocal translocation. The live birth rate per embryo transfer was found to be 66. 6% (12/18). Conclusion: PGT-SR is a useful tool in selecting normal or balanced embryos for transfer in IVF, which could lead to a pregnancy by reducing the chance of miscarriages due to chromosome Aneuploidy in couples with Balanced chromosomal rearrangements.

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APA: Copy

Shetty, Sachin, Nair, Jiny, Johnson, Jnapti, Shetty, Navya, Kumar J, Ajay, Thondehalmath, Nirmala, Ganesh, Deepanjali, R Bhat, Vidyalakshmi, M., Sajana, Anjana, R., Nayak, Rajsekhar, Gunasheela, Devika, S Kadandale, Jayarama, & Shetty, Swathi. (2022). Preimplantation Genetic Testing for Couples with Balanced Chromosomal Rearrangements. JOURNAL OF REPRODUCTION AND INFERTILITY, 23(3), 213-223. SID. https://sid.ir/paper/988060/en

Vancouver: Copy

Shetty Sachin, Nair Jiny, Johnson Jnapti, Shetty Navya, Kumar J Ajay, Thondehalmath Nirmala, Ganesh Deepanjali, R Bhat Vidyalakshmi, M. Sajana, Anjana R., Nayak Rajsekhar, Gunasheela Devika, S Kadandale Jayarama, Shetty Swathi. Preimplantation Genetic Testing for Couples with Balanced Chromosomal Rearrangements. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2022;23(3):213-223. Available from: https://sid.ir/paper/988060/en

IEEE: Copy

Sachin Shetty, Jiny Nair, Jnapti Johnson, Navya Shetty, Ajay Kumar J, Nirmala Thondehalmath, Deepanjali Ganesh, Vidyalakshmi R Bhat, Sajana M., R. Anjana, Rajsekhar Nayak, Devika Gunasheela, Jayarama S Kadandale, and Swathi Shetty, “Preimplantation Genetic Testing for Couples with Balanced Chromosomal Rearrangements,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 23, no. 3, pp. 213–223, 2022, [Online]. Available: https://sid.ir/paper/988060/en

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