مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

33
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

33
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Phytochemical Screening and Antinociceptive Activity of the Hydroalcoholic Extract of Potentilla reptans L.

Pages

  277-284

Abstract

 Background: Potentilla species have traditionally been used as anti-inflammatory and analgesic agents in Iran and other countries. Objectives: This study aimed to investigate the antinociceptive effect of Potentilla reptans L., which has a wide distribution in the north of Iran. Methods: The biological activities of the hydroalcoholic extract of P. reptans aerial parts have been investigated using the acetic acid-induced writhing, hot plate, and Rotarod tests in the male mice. In addition, the phytochemical profile of the extract has been evaluated. Results: The phytochemical investigation detected secondary metabolites such as flavonoids, saponins, triterpenoids, and tannins in the extract. Moreover, the Mean±, SD total phenolic and tannin contents of the extract were 251±, 2. 08 and 111. 5±, 1. 3 mg gallic acid equivalents per gram of dried extract, respectively. Also, the Mean±, SD total flavonoid content was 29. 42±, 3. 31 mg quercetin equivalents per gram of dried extract. Oral administration of the extract (100, 300, and 500 mg/kg) dose-dependently reduced the number of writhing responses induced by acetic acid and increased the reaction time in the hot-plate test. The antinociceptive effect of the extract, similar to morphine, was significantly antagonized by naloxone (4 mg/kg,IP) in the writhing test. In the Rotarod test, none of the extract doses used in the experiment caused a loss of locomotor activity. Conclusion: In this study, the hydroalcoholic extract of P. reptans showed a practical antinociceptive effect in hot plate and writhing tests. It seems that Opioid receptors mediate the observed effect.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    AHANGAR, NEMATOLLAH, Bakhshi Jouybari, Hossein, DAVOODI, ALI, & SHAHANI, SOMAYEH. (2021). Phytochemical Screening and Antinociceptive Activity of the Hydroalcoholic Extract of Potentilla reptans L.. PHARMACEUTICAL AND BIOMEDICAL RESEARCH, 7(4), 277-284. SID. https://sid.ir/paper/988489/en

    Vancouver: Copy

    AHANGAR NEMATOLLAH, Bakhshi Jouybari Hossein, DAVOODI ALI, SHAHANI SOMAYEH. Phytochemical Screening and Antinociceptive Activity of the Hydroalcoholic Extract of Potentilla reptans L.. PHARMACEUTICAL AND BIOMEDICAL RESEARCH[Internet]. 2021;7(4):277-284. Available from: https://sid.ir/paper/988489/en

    IEEE: Copy

    NEMATOLLAH AHANGAR, Hossein Bakhshi Jouybari, ALI DAVOODI, and SOMAYEH SHAHANI, “Phytochemical Screening and Antinociceptive Activity of the Hydroalcoholic Extract of Potentilla reptans L.,” PHARMACEUTICAL AND BIOMEDICAL RESEARCH, vol. 7, no. 4, pp. 277–284, 2021, [Online]. Available: https://sid.ir/paper/988489/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button