The relationship between the cytokines and hs-CRP levels in children with autism and their comparison with healthy ones

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Ansari Kolachahi Soleyman; HOJJATI ZIDASHTI ZAHRA; Elmieh Alireza; BIDABADI ELHAM; Filli Jafar

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2019 | Volume:29 | Issue:3 Page(s): 240-248

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Title

The relationship between the cytokines and hs-CRP levels in children with autism and their comparison with healthy ones

Author(s)

Keywords

Autism spectrum disorderQ1

C-reactive proteinQ2

Inflammatory cytokinesQ1

Immune systemQ2

Abstract

Background: Previous studies suggest that dysregulation of the Immune system is involved in the pathophysiology of Autism spectrum disorders (ASD). The aim of the present study was to investigate some pre-and anti-Inflammatory cytokines in the serum of children with autism and healthy children and to determine the correlation between these cytokines and hs-CRP. Materials and methods: Serum levels of IL-1β , IL-1RA, IL-6, IL-10, TNF-α cytokines and hs-CRP were assessed in twenty boys with Autism spectrum disorder, aged 6 to 14 years, and 20 healthy controls. To analyze the data, multivariate analysis of variance analysis was used to compare the variables in the two groups, and Pearson correlation coefficient was utilized to assess the relationship between the levels of the cytokines and hs-CRP at the level of 0, 05. SPSS software version 21 was used. Results: The results showed that the level of all cytokines as well as hs-CRP in the autistic group was significantly higher than normal children (p<0. 001), but there was no statistically significant relationship between cytokines and hs-CRP levels in children with autism (p>0. 05). Conclusion: The results suggest that abnormal immune responses such as increased levels of cytokines can be served as one of the biological markers of ASD.

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References

The immune system, cytokines, and biomarkers in autism spectrum disorder

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APA: Copy

Ansari Kolachahi, Soleyman, HOJJATI ZIDASHTI, ZAHRA, Elmieh, Alireza, BIDABADI, ELHAM, & Filli, Jafar. (2019). The relationship between the cytokines and hs-CRP levels in children with autism and their comparison with healthy ones. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 29(3 ), 240-248. SID. https://sid.ir/paper/98862/en

Vancouver: Copy

Ansari Kolachahi Soleyman, HOJJATI ZIDASHTI ZAHRA, Elmieh Alireza, BIDABADI ELHAM, Filli Jafar. The relationship between the cytokines and hs-CRP levels in children with autism and their comparison with healthy ones. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2019;29(3 ):240-248. Available from: https://sid.ir/paper/98862/en

IEEE: Copy

Soleyman Ansari Kolachahi, ZAHRA HOJJATI ZIDASHTI, Alireza Elmieh, ELHAM BIDABADI, and Jafar Filli, “The relationship between the cytokines and hs-CRP levels in children with autism and their comparison with healthy ones,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 29, no. 3 , pp. 240–248, 2019, [Online]. Available: https://sid.ir/paper/98862/en

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