HISTOLOGICAL, HISTOMETRICAL AND THYROID HORMONES SERUM LEVEL EVALUATION AFTER CHRONIC NICOTINE EXPOSURE IN MICE

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FAZELIPOOR SIMIN; HADIPOUR JAHROMI MAHSA; BEHTASH NEGAR; TOOTIYAN ZAHRA; SHAFIE MINOO; ASADI FARDIN; CHEGINI HAMID REZA

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2012 | Volume:21 | Issue:4 (66) Page(s): 268-274

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Title

HISTOLOGICAL, HISTOMETRICAL AND THYROID HORMONES SERUM LEVEL EVALUATION AFTER CHRONIC NICOTINE EXPOSURE IN MICE

Author(s)

Keywords

NICOTINEQ3

THYROIDQ2

HISTOLOGYQ3

HISTOMETRYQ3

Abstract

Background: NICOTINE is an ingredient of cigarette smoke that has a lot of psychological and physical effects on addicted persons.The aim of this study was to evaluate NICOTINE effects on functional and histological alteration in THYROID gland that has important role on metabolic activities.Materials and methods: In this experimental study, 40 mature male mice (25-30 gr) were divided to one control group and 3 experimental groups that received NICOTINE with dosage of 100, 200 and 400 µg/kg via oral gavage once a day for 60 days.Then, T3, T4 and TSH serum levels were measured and histomorphometric evaluation of THYROID gland was done.Results: Significant decrease in body weight and THYROID follicular epithelial height and significant increase in serum level of T3 were noted.Conclusion: This study showed that NICOTINE can cause alteration on metabolic activities of THYROID gland via the increase of T3 serum level and the decrease of follicular epithelial height.

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APA: Copy

FAZELIPOOR, SIMIN, HADIPOUR JAHROMI, MAHSA, BEHTASH, NEGAR, TOOTIYAN, ZAHRA, SHAFIE, MINOO, ASADI, FARDIN, & CHEGINI, HAMID REZA. (2012). HISTOLOGICAL, HISTOMETRICAL AND THYROID HORMONES SERUM LEVEL EVALUATION AFTER CHRONIC NICOTINE EXPOSURE IN MICE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 21(4 (66)), 268-274. SID. https://sid.ir/paper/98883/en

Vancouver: Copy

FAZELIPOOR SIMIN, HADIPOUR JAHROMI MAHSA, BEHTASH NEGAR, TOOTIYAN ZAHRA, SHAFIE MINOO, ASADI FARDIN, CHEGINI HAMID REZA. HISTOLOGICAL, HISTOMETRICAL AND THYROID HORMONES SERUM LEVEL EVALUATION AFTER CHRONIC NICOTINE EXPOSURE IN MICE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;21(4 (66)):268-274. Available from: https://sid.ir/paper/98883/en

IEEE: Copy

SIMIN FAZELIPOOR, MAHSA HADIPOUR JAHROMI, NEGAR BEHTASH, ZAHRA TOOTIYAN, MINOO SHAFIE, FARDIN ASADI, and HAMID REZA CHEGINI, “HISTOLOGICAL, HISTOMETRICAL AND THYROID HORMONES SERUM LEVEL EVALUATION AFTER CHRONIC NICOTINE EXPOSURE IN MICE,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 21, no. 4 (66), pp. 268–274, 2012, [Online]. Available: https://sid.ir/paper/98883/en

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