GENOME EDITING FROM BENCH TO CLINIC BY CRISPR/CAS9

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NOORI DALOII MOHAMMAD REZA; KAVOOSI SAEEDEH; Rahimi Rad Nazanin

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2018 | Volume:28 | Issue:1 Page(s): 1-15

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Information Journal Paper

Title

GENOME EDITING FROM BENCH TO CLINIC BY CRISPR/CAS9

Author(s)

NOORI DALOII MOHAMMAD REZA | KAVOOSI SAEEDEH | Rahimi Rad Nazanin | Issue Writer Certificate

Keywords

CYSTIC GENOME EDITINGQ1

CRISPR/CAS9Q1

TARGETING SPECIFICITYQ1

NOVEL THERAPIESQ1

Abstract

Background: Engineered molecular scissors invention beside their ability to conduct site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes. These technologies could improve researchers’ understanding of the molecular underpinnings of disease states and facilitate novel medical genetic therapeutic applications. The CRISPR/CAS9 system’ s simplicity, facile engineering and amenability to multiplexing make it the system of choice for many applications. CRISPR/CAS9 has been used to generate disease models to study genetic diseases. It is expected that in the near future researchers will refinement this technology in various aspects of the CRISPR/CAS9 system, including the system’ s precision, delivery and control over the outcome of the on-targrt activity during repair process. Here, we discuss the CRISPR/CAS9 history, type of CRISPR systems, the status of this technology in the field of genome editing and its use in new treatments for diseases such as genetics, cancer, etc.

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APA: Copy

NOORI DALOII, MOHAMMAD REZA, KAVOOSI, SAEEDEH, & Rahimi Rad, Nazanin. (2018). GENOME EDITING FROM BENCH TO CLINIC BY CRISPR/CAS9. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 28(1 ), 1-15. SID. https://sid.ir/paper/98913/en

Vancouver: Copy

NOORI DALOII MOHAMMAD REZA, KAVOOSI SAEEDEH, Rahimi Rad Nazanin. GENOME EDITING FROM BENCH TO CLINIC BY CRISPR/CAS9. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2018;28(1 ):1-15. Available from: https://sid.ir/paper/98913/en

IEEE: Copy

MOHAMMAD REZA NOORI DALOII, SAEEDEH KAVOOSI, and Nazanin Rahimi Rad, “GENOME EDITING FROM BENCH TO CLINIC BY CRISPR/CAS9,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 28, no. 1 , pp. 1–15, 2018, [Online]. Available: https://sid.ir/paper/98913/en

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